Intrinsically generated neural activity propagates through the developing auditory system to
promote maturation and refinement of sound processing circuits prior to hearing onset. This …

Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin
30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and …

Pathogenic variants in GJB2, the gene encoding connexin 26, are the most common cause
of autosomal-recessive hereditary deafness. Despite this high prevalence, pathogenic …

Mutations in the Gjb2 gene, which encodes a gap junction protein connexin26 (Cx26), are
the most prevalent form of hereditary deafness in humans and represent about half of non …

Mutations in the connexin26 gene (GJB2) are the most common genetic cause of congenital
bilateral non-syndromic sensorineural hearing loss. Transgenic mice were established …

Abstract Mutations of Connexin 26 (Cx26, GJB2), which is a predominant gap junction
isoform in the cochlea, can induce high incidence of nonsyndromic hearing loss. We …

Hereditary hearing loss is one of the most prevalent inherited human birth defects, affecting
one in 2000. A strikingly high proportion (50%) of congenital bilateral nonsyndromic …

Neurons in the developing auditory system exhibit spontaneous bursts of activity before
hearing onset. How this intrinsically generated activity influences development remains …

Mutations in GJB2, which codes for the gap junction (GJ) protein connexin26 (Cx26), are the
most common causes of human nonsyndromic hereditary deafness. We inoculated modified …

Mutations in the GJB2 gene [which encodes connexin 26 (Cx26)] are the most common
causes of hereditary hearing loss in humans, and previous studies showed postnatal …