The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …

Colistin, a cationic polypeptide antibiotic, has reappeared in human medicine as a last-line
treatment option for multidrug-resistant Gram-negative bacteria (MDR-GNB). Colistin is …

Colistin is an old antimicrobial that has been revitalized as last-resort treatment against
multidrug-resistant (MDR) gram-negative bacterial infections. However, colistin has been …

In this Leading article, we summarize current knowledge of the occurrence of the first and so
far only transferable colistin resistance gene, mcr-1. Its location on a conjugative plasmid is …

Colistin, also known as polymyxin E, is an antimicrobial agent that is effective against a
variety of Gram-negative bacilli, especially the Enterobacteriaceae family. Recently, the wide …

Colistin has been extensively used since the middle of the last century in animals,
particularly in swine, for the control of enteric infections. Colistin is presently considered the …

Antimicrobial resistance (AMR) poses a serious threat to human, animal and environmental
health worldwide. Colistin has regained importance as a last-resort treatment against multi …

Background The emergence of colistin-resistant Enterobacterales is a global public health
concern, yet colistin is still widely used in animals that are used for food as treatment …

Colistin has been used in veterinary medicine for decades, mainly for the prevention and
treatment of Enterobacteriaceae infections. However, data regarding colistin resistance in …

Colistin has been re-assessed as a critically important antimicrobial in humans due to its
efficacy against multi-drug resistant Gram-negative bacteria, in particular P. aeruginosa, A …