Role of Nrf2 in disease: Novel molecular mechanisms and therapeutic approaches–Pulmonary disease/asthma
C Audousset, T McGovern, JG Martin - Frontiers in Physiology, 2021 - frontiersin.org
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a major transcription factor involved in
redox homeostasis and in the response induced by oxidative injury. Nrf2 is present in an …
redox homeostasis and in the response induced by oxidative injury. Nrf2 is present in an …
Role of Nrf2 and its activators in respiratory diseases
Q Liu, Y Gao, X Ci - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …
Noblesse Oblige: NRF2 Functions in the Airways
HY Cho, SR Kleeberger - American Journal of Respiratory Cell and …, 2014 - atsjournals.org
The transcription factor, nuclear factor (NF), erythroid-derived 2–related factor 2 (NRF2), was
discovered nearly 2 decades ago. Since then, over 4,000 papers have been published on …
discovered nearly 2 decades ago. Since then, over 4,000 papers have been published on …
An update on the role of Nrf2 in respiratory disease: molecular mechanisms and therapeutic approaches
J Lee, J Jang, SM Park, SR Yang - International Journal of Molecular …, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor (Nrf2) is a transcriptional activator of the cell
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …
The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury
Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor
that upregulates antioxidant response elements (AREs)-mediated expression of antioxidant …
that upregulates antioxidant response elements (AREs)-mediated expression of antioxidant …
NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease
A Boutten, D Goven, E Artaud-Macari… - Trends in molecular …, 2011 - cell.com
Several convergent destructive mechanisms such as oxidative stress, alveolar cell
apoptosis, extracellular matrix proteolysis and chronic inflammation contribute to chronic …
apoptosis, extracellular matrix proteolysis and chronic inflammation contribute to chronic …
Nrf2 defends the lung from oxidative stress
HY Cho, SP Reddy, SR Kleeberger - Antioxidants & redox signaling, 2006 - liebertpub.com
Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region
leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants …
leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants …
Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models
HY Cho, SR Kleeberger - Archives of toxicology, 2015 - Springer
Nrf2 is a key transcription factor for antioxidant response element (ARE)-bearing genes
involved in diverse host defense functions including redox balance, cell cycle, immunity …
involved in diverse host defense functions including redox balance, cell cycle, immunity …
Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway
A Boutten, D Goven, J Boczkowski… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: Oxidative stress has been implicated in the pathogenesis of
pulmonary emphysema. Nuclear factor erythroid-2-related factor 2 (Nrf2) a major antioxidant …
pulmonary emphysema. Nuclear factor erythroid-2-related factor 2 (Nrf2) a major antioxidant …
The role of Nrf2 in pulmonary fibrosis: molecular mechanisms and treatment approaches
Y Wang, J Wei, H Deng, L Zheng, H Yang, X Lv - Antioxidants, 2022 - mdpi.com
Pulmonary fibrosis is a chronic, progressive, incurable interstitial lung disease with high
mortality after diagnosis and remains a global public health problem. Despite advances and …
mortality after diagnosis and remains a global public health problem. Despite advances and …
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