Huntington's disease (HD) is an inherited neurodegenerative disease caused by a
glutamine repeat expansion in huntingtin protein. Transcriptional deregulation and altered …

Huntington's disease (HD) is a fatal, dominantly inherited disorder caused by polyglutamine
repeat expansion in the huntingtin (htt) gene. Here, we observe that HD mice develop …

Huntington's disease (HD) is caused by CAG repeat expansions in the (huntingtin htt) gene,
yielding proteins containing polyglutamine repeats that become misfolded and resist …

The coactivator PGC-1α is a key regulator of mitochondrial biogenesis and respiration,
mediating expression of several transcription factors required for these programs. Three new …

Mitochondrial dysfunction is a common hallmark of ageing-related diseases involving
neurodegeneration. Huntington's disease (HD) is one of the most common monogenetic …

Huntington's disease (HD) is an inherited progressive neurodegenerative disorder
associated with involuntary abnormal movements (chorea), cognitive deficits and psychiatric …

We investigated the ability of AMP-activated protein kinase (AMPK) to activate PPARγ
coactivator-1α (PGC-1α) in the brain, liver and brown adipose tissue (BAT) of the NLS-N171 …

Many pathways have been proposed as contributing to Huntington's disease (HD)
pathogenesis, but generally the in vivo effects of their perturbation have not been compared …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by
a CAG trinucleotide expansion in the Huntingtin (Htt) gene. The resultant mutant Htt protein …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is
caused by a pathological expansion of CAG repeats within the gene encoding for a 350kD …