The impact of environmental contaminants on extracellular vesicles and their key molecular regulators: A literature and database‐driven review

CK Carberry, JE Rager - Environmental and molecular …, 2023 - Wiley Online Library
Exposure to environmental chemicals is now well recognized as a significant factor
contributing to the global burden of disease; however, there remain critical gaps in …

Approaches to incorporate extracellular vesicles into exposure science, toxicology, and public health research

CK Carberry, D Keshava, A Payton, GJ Smith… - Journal of exposure …, 2022 - nature.com
Extracellular vesicles (EVs) represent small, membrane-enclosed particles that are derived
from parent cells and are secreted into the extracellular space. Once secreted, EVs can then …

Environmental exposures and extracellular vesicles: indicators of systemic effects and human disease

CM Eckhardt, AA Baccarelli, H Wu - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review Environmental pollutants contribute to the pathogenesis of
numerous diseases including chronic cardiovascular, respiratory, and neurodegenerative …

Extracellular vesicles in toxicological studies: key roles in communication between environmental stress and adverse outcomes

Y Qin, L Long, Q Huang - Journal of Applied Toxicology, 2020 - Wiley Online Library
External stressors, especially environmental toxicants can disturb biological homeostasis
and thus lead to adverse health effects. However, there is limited understanding of how cells …

Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis

P Kalita-de Croft, S Sharma, L Sobrevia… - Molecular Aspects of …, 2022 - Elsevier
The influence of environmental factors on an individual, from conception onwards, is defined
as the exposome. It can be categorized into the external exposome, which includes external …

Exosomes as mediators of chemical-induced toxicity

D Rokad, H Jin, V Anantharam, A Kanthasamy… - Current environmental …, 2019 - Springer
Abstract Purpose of Review This review provides information regarding how exosomes may
contribute to environmental chemical-induced pathogenesis of chronic diseases. In …

Focus on extracellular vesicles: introducing the next small big thing

H Kalra, GPC Drummen, S Mathivanan - International journal of molecular …, 2016 - mdpi.com
Intercellular communication was long thought to be regulated exclusively through direct
contact between cells or via release of soluble molecules that transmit the signal by binding …

Exosomes in toxicology: relevance to chemical exposure and pathogenesis of environmentally linked diseases

DS Harischandra, S Ghaisas, D Rokad… - Toxicological …, 2017 - academic.oup.com
Chronic exposure to environmental toxins has been known to initiate or aggravate various
neurological disorders, carcinomas and other adverse health effects. Uptake by naïve cells …

Environmental pollutants and exosomes: A new paradigm in environmental health and disease

A Javdani-Mallak, I Salahshoori - Science of The Total Environment, 2024 - Elsevier
This study investigates the intricate interplay between environmental pollutants and
exosomes, shedding light on a novel paradigm in environmental health and disease …

In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo: Part I: Health and Normal Physiology

AG Yates, RC Pink, U Erdbrügger… - Journal of …, 2022 - Wiley Online Library
Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are
now known to mediate physiological and pathological functions throughout the body. We …