Natural products have long been used as drugs to treat a wide array of human diseases.
The lead compounds discovered from natural sources are used as novel templates for …

Alzheimer's disease (AD) is the most common neurodegenerative disease, and its incidence
is increasing worldwide with increased lifespan. Currently, there is no effective treatment to …

Abstract Sirtuins or Sir (Silent information regulator) are NAD+-dependent enzymes playing
an important part in the pathogenesis and treatment of various disorders. They have …

Alzheimer's disease (AD) is a neurodegenerative disease mainly characterized by
progressive cognitive dysfunction and memory impairment. Recent studies have shown that …

Flavonoids are polyphenolic secondary metabolites synthesized by plants and fungus with
various pharmacological effects. Due to their plethora of biological activities, they have been …

Polyphenols synthesized by plants and fungi have various pharmacological effects. The
ability of polyphenols to modulate sirtuins has gained considerable interest due to the role of …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide+ (NAD+) dependent enzyme and
stress response protein that has sparked the curiosity of many researchers in different …

Abstract Sirtuin 1 (SIRT1) is a class III family of protein histone deacetylases involved in
NAD+-dependent deacetylation reactions. It has been suggested that SIRT1 activators may …

Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …