The appropriate regulation of intracellular calcium is a requirement for proper cell function
and survival. This review focuses on the effects of proinflammatory cytokines on calcium …

Pancreatic beta (β) cell dysfunction results in compromised insulin release and, thus, failed
regulation of blood glucose levels. This forms the backbone of the development of diabetes …

Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …

Abstract Background The divalent cation Calcium (Ca 2+) regulates a wide range of
processes in disparate cell types. Within insulin-producing β-cells, increases in cytosolic Ca …

Emerging insulin resistance is normally compensated by increased insulin production of
pancreatic β-cells, thereby maintaining normoglycemia. However, it is unclear whether this …

Molecular cascades responsible for Ca 2+ homeostasis and Ca 2+ signalling could be
assembled in highly plastic toolkits that define physiological adaptation of cells to the …

In healthy pancreatic islets, glucose-stimulated changes in intracellular calcium ([Ca 2+] i)
provide a reasonable reflection of the patterns and relative amounts of insulin secretion. We …

Cumulative evidence reveals that diabetes is a condition in which cell Ca 2+ homeostasis is
impaired. Defects in cell Ca 2+ regulation were found in erythrocytes, cardiac muscle …

Abstract The cytoplasmic Ca 2+ concentration ([Ca 2+] cyt) regulates a vast number of
cellular functions, including insulin secretion from beta cells. The major physiological insulin …

Pro-inflammatory cytokines are important mediators of islet inflammation, leading to beta cell
death in type 1 diabetes. Although alterations in both endoplasmic reticulum (ER) and …