Fungi, including yeasts, molds, and mushrooms, proliferate on decaying matter and then
adopt quiescent forms once nutrients are depleted. This review explores how fungi use …

In response to limited nutrients, fungal cells exit the primary growth phase, enter the
stationary phase, and cease proliferation. Although fundamental to microbial physiology in …

The sirtuins are members of the NAD+-dependent histone deacetylase family that contribute
to various cellular functions that affect aging, disease, and cancer development in …

Protein acetylation is a crucial post-translational modification that controls gene expression
and a variety of biological processes. Sirtuins, a prominent class of NAD+-dependent lysine …

Evolutionary adaptation increases the fitness of a species in its environment. It can occur
through rewiring of gene regulatory networks, such that an organism responds appropriately …

Aspergillus fumigatus represents a public health problem due to the high mortality rate in
immunosuppressed patients and the emergence of antifungal-resistant isolates. Protein …

Sirtuins are evolutionarily conserved NAD-dependent deacetylases that catalyze the
cleavage of NAD+ into nicotinamide (NAM), which can act as a pan-sirtuin inhibitor in …

Late-stage cultures of filamentous fungi under nutrient starvation produce valuable
secondary metabolites such as pharmaceuticals and pigments, as well as deleterious …

Phytopathogenic fungi must adapt to the different environmental conditions found during
infection and avoid the immune response of the plant. For these adaptations, fungi must …

Sirtuins, a family of NAD+-dependent deacetylases, help organisms to respond to metabolic
and genotoxic stress through diverse pathways, including metabolic homeostasis, cell …