An improved understanding of human T cell-mediated immunity in COVID-19 is important for
optimizing therapeutic and vaccine strategies. Experience with influenza shows that …

T cell immunity is central for the control of viral infections. To characterize T cell immunity,
but also for the development of vaccines, identification of exact viral T cell epitopes is …

Cellular immunity is important in determining the disease severity of COVID-19 patients.
However, current understanding of SARS-CoV-2 epitopes mediating cellular immunity is …

The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and
there is an urgent need to map the landscape of immunogenic and immunodominant …

Despite the growing knowledge of T cell responses in COVID-19 patients, there is a lack of
detailed characterizations for T cell-antigen interactions and T cell functions. Here, with a …

Pathogen-specific CD8+ T cell responses restricted by the nonpolymorphic nonclassical
class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections …

Background Recent studies have provided evidence of T cell reactivity to Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of non-infected …

In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …

Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development,
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …

Emerging data indicate that SARS-CoV-2-specific CD8+ T cells targeting different viral
proteins are detectable in up to 70% of convalescent individuals,,,–. However, very little …