Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation

SH Wang, L de Oliveira Alvares, K Nader - Nature neuroscience, 2009 - nature.com
Memory reconsolidation has been demonstrated in various tasks and species, suggesting it
is a fundamental process. However, there are experimental parameters that can inhibit …

Memory reconsolidation mediates the strengthening of memories by additional learning

JLC Lee - Nature neuroscience, 2008 - nature.com
Memories are dynamic, rather than static, in nature. The reactivation of a memory through re-
exposure to salient training stimuli results in its destabilization, necessitating a …

Learning and reconsolidation implicate different synaptic mechanisms

Y Li, EG Meloni, WA Carlezon Jr… - Proceedings of the …, 2013 - National Acad Sciences
Synaptic mechanisms underlying memory reconsolidation after retrieval are largely
unknown. Here we report that synapses in projections to the lateral nucleus of the amygdala …

Reactivation enables memory updating, precision-keeping and strengthening: exploring the possible biological roles of reconsolidation

LDO Alvares, AP Crestani, LF Cassini, J Haubrich… - Neuroscience, 2013 - Elsevier
Although much has been learned regarding the molecular and cellular mechanisms of
memory reconsolidation, its actual biological function remains unclear. In this work we …

Increasing the GluN2A/GluN2B ratio in neurons of the mouse basal and lateral amygdala inhibits the modification of an existing fear memory trace

R Holehonnur, AJ Phensy, LJ Kim… - Journal of …, 2016 - Soc Neuroscience
Reconsolidation updating is a form of memory modification in which an existing memory can
become destabilized upon retrieval and subsequently be modified via protein-synthesis …

Reconsolidation and the dynamic nature of memory

K Nader - Cold Spring Harbor Perspectives in Biology, 2015 - cshperspectives.cshlp.org
Memory reconsolidation is the process in which reactivated long-term memory (LTM)
becomes transiently sensitive to amnesic agents that are effective at consolidation. The …

Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala

V Doyere, J Dębiec, MH Monfils, GE Schafe… - Nature …, 2007 - nature.com
When reactivated, memories enter a labile, protein synthesis–dependent state, a process
referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a …

Characterization of fear memory reconsolidation

S Duvarci, K Nader - Journal of Neuroscience, 2004 - Soc Neuroscience
Reactivation of consolidated memories returns them to a protein synthesis-dependent state.
One interpretation of these findings is that the memory reconsolidates after use. Two …

Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala

J Dębiec, JE LeDoux - Neuroscience, 2004 - Elsevier
Consolidation is a process through which labile memories are made persistent [Science 287
(2000) 248];[Annu Rev Psychol 55 (2004) 51]. When retrieved, a consolidated memory is …

[HTML][HTML] Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation

J Haubrich, M Bernabo, K Nader - elife, 2020 - elifesciences.org
Memory reconsolidation is a fundamental plasticity process in the brain that allows
established memories to be changed or erased. However, certain boundary conditions limit …