[HTML][HTML] Advancing pharmacogenomics from single-gene to preemptive testing
Pharmacogenomic testing can be an effective tool to enhance medication safety and
efficacy. Pharmacogenomically actionable medications are widely used, and approximately …
efficacy. Pharmacogenomically actionable medications are widely used, and approximately …
Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing
SL Van Driest, Y Shi, EA Bowton… - Clinical …, 2014 - Wiley Online Library
Since September 2010, more than 10,000 patients have undergone preemptive, panel‐
based pharmacogenomic testing through the Vanderbilt Pharmacogenomic Resource for …
based pharmacogenomic testing through the Vanderbilt Pharmacogenomic Resource for …
Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers
HM Dunnenberger, KR Crews… - Annual review of …, 2015 - annualreviews.org
Although the field of pharmacogenetics has existed for decades, practioners have been slow
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …
Preemptive panel-based pharmacogenetic testing: the time is now
KW Weitzel, LH Cavallari, LJ Lesko - Pharmaceutical research, 2017 - Springer
While recent discoveries have paved the way for the use of genotype-guided prescribing in
some clinical environments, significant debate persists among clinicians and researchers …
some clinical environments, significant debate persists among clinicians and researchers …
Are patients willing to incur out-of-pocket costs for pharmacogenomic testing?
SJ Bielinski, JL St Sauver, JE Olson… - The …, 2017 - nature.com
Genetic modulation of drug response can cause serious, potentially life-threatening adverse
drug reactions, can increase susceptibility to drug–drug interactions and can diminish or …
drug reactions, can increase susceptibility to drug–drug interactions and can diminish or …
[HTML][HTML] Pharmacogenomics cascade testing (PhaCT): a novel approach for preemptive pharmacogenomics testing to optimize medication therapy
The implementation of pharmacogenomics (PGx) has come a long way since the dawn of
utilizing pharmacogenomic data in clinical patient care. However, the potential benefits of …
utilizing pharmacogenomic data in clinical patient care. However, the potential benefits of …
Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping
JS Schildcrout, JC Denny, E Bowton… - Clinical …, 2012 - Wiley Online Library
Routine integration of genotype data into drug decision making could improve patient safety,
particularly if many relevant genetic variants can be assayed simultaneously before …
particularly if many relevant genetic variants can be assayed simultaneously before …
Updating the landscape of direct-to-consumer pharmacogenomic testing
KK Filipski, JD Murphy… - … and personalized medicine, 2017 - Taylor & Francis
Pharmacogenomics has identified important drug–gene interactions that affect the safety
and efficacy of medications. Direct-to-consumer genetic testing, when first introduced …
and efficacy of medications. Direct-to-consumer genetic testing, when first introduced …
[HTML][HTML] Preemptive pharmacogenetic testing: exploring the knowledge and perspectives of US payers
NJ Keeling, MM Rosenthal, D West-Strum, AS Patel… - Genetics in …, 2019 - Elsevier
Purpose Preemptive pharmacogenetic testing aims to optimize medication use by having
genetic information at the point of prescribing. Payers' decisions influence implementation of …
genetic information at the point of prescribing. Payers' decisions influence implementation of …
[HTML][HTML] Incidence of exposure of patients in the United States to multiple drugs for which pharmacogenomic guidelines are available
Pre-emptive pharmacogenomic (PGx) testing of a panel of genes may be easier to
implement and more cost-effective than reactive pharmacogenomic testing if a sufficient …
implement and more cost-effective than reactive pharmacogenomic testing if a sufficient …