Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

The CRISPR-Cas9 system has revolutionized our ability to precisely modify the genome and
has led to gene editing in clinical applications. Comprehensive analysis of gene editing …

CRISPR–Cas9 is poised to become the gene editing tool of choice in clinical contexts. Thus
far, exploration of Cas9-induced genetic alterations has been limited to the immediate …

CRISPR-Cas9 genome editing has promising therapeutic potential for genetic diseases and
cancers, but safety could be a concern. Here we use whole genomic analysis by 10x linked …

CRISPR-Cas9 has quickly become the method of choice for genome editing, with multiple
publications describing technical advances and novel applications. It has been widely …

The recent emergence of gene editing technologies, in particular CRISPR/Cas, has enabled
rapid generation of disease models and provides a novel approach for the treatment of …

CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic
mutations that affect the efficiency and precision of its ability to edit the genome. Reducing …

Background CRISPR-Cas9 is a revolutionary genome editing technique that allows for
efficient and directed alterations of the eukaryotic genome. This relatively new technology …

The mechanism underlying unwanted structural variations induced by CRISPR-Cas9
remains poorly understood, and no effective strategy is available to inhibit the generation of …

Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome
editing. However, the events that lead to these karyotypic changes in embryos after Cas9 …