Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

Alterations in cerebral cortex connectivity lead to intellectual disability and in Down
syndrome, this is associated with a deficit in cortical neurons that arises during prenatal …

Down syndrome (DS) is one of the most common genetic disorders accompanying with
mental retardation, cognitive impairment, and deficits in learning and memory. The brains …

We previously obtained evidence for reduced cell proliferation in the dentate gyrus (DG) of
fetuses with Down syndrome (DS), suggesting that the hippocampal hypoplasia seen in …

Down's syndrome neurophenotypes are characterized by mental retardation and a
decreased brain volume. To identify whether deficits in proliferation could be responsible for …

Down syndrome is the most frequent genetic cause of mental retardation, having an
incidence of 1 in 700 live births. In the present study we used a transgenic mouse in vivo …

Simple Summary Down Syndrome, which is due to the presence of three copies of
chromosome 21, always presents with mental retardation, possibly caused by defects in the …

Down syndrome (DS) is the most frequent cause of human congenital mental retardation.
Cognitive deficits in DS result from perturbations of normal cellular processes both during …

Down syndrome (DS) is associated with many neural defects, including reduced brain size
and impaired neuronal proliferation, highly contributing to the mental retardation. Those …

Evidence in mouse models for Down syndrome (DS) and human fetuses with DS clearly
shows severe neurogenesis impairment in various telencephalic regions, suggesting that …