Peripheral nerve injury in humans can produce a persistent pain state characterized by
spontaneous pain and painful responses to normally innocuous stimuli (allodynia). Here we …

Hyperalgesia is a characteristic of inflammation and is mediated, in part, by an increase in
the excitability of spinal neurons. Although substance P does not appear to mediate fast …

The original proposal that substance P is involved in the regulation of nociceptive
information at the first sensory synapse in the spinal cord has been substantiated by a wide …

Although many studies have demonstrated a role for substance P in pain, there have been
conflicting reports implicating the involvement of substance P in neuropathic pain models. In …

Substance P (SP) has been widely studied as a mediator of nociception. The release of SP
from primary afferent neurons is increased during nociception, and SP activates neurokinin …

Opiate analgesia in the spinal cord is impaired during neuropathic pain. We hypothesized
that this is caused by a decrease in μ-opioid receptor inhibition of neurotransmitter release …

The substance Preceptor neurokinin-1 is expressed by a subset of neurons in the rat spinal
cord. We have combined immunostaining for Fos, a marker of noxious peripheral …

Mechanisms underlying neuropathic pain states are poorly understood. We have compared
mechanisms mediating enhanced nociception of four established models of neuropathic …

The generation of knock-out and transgenic mice offers a promising approach to the
identification of novel biochemical factors that contribute to persistent pain conditions. To …

That substance P (SP) contributes in some way to spinal nociceptive processing has been
known for many years. However, the contribution of SP and NK-1 receptors to the generation …