Role of the tumor microenvironment in regulating apoptosis and cancer progression
Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional
cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy …
cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy …
Microenvironmental effects of cell death in malignant disease
CD Gregory, CA Ford, JJLP Voss - Apoptosis in Cancer Pathogenesis and …, 2016 - Springer
Although apoptosis is well recognized as a cell death program with clear anticancer roles,
accumulating evidence linking apoptosis with tissue repair and regeneration indicates that …
accumulating evidence linking apoptosis with tissue repair and regeneration indicates that …
Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues
CD Gregory, JD Pound - The Journal of pathology, 2011 - Wiley Online Library
Here we consider the impact of the physiological cell‐death programme on normal tissue
homeostasis and on disease pathogenesis, with particular reference to evolution and …
homeostasis and on disease pathogenesis, with particular reference to evolution and …
Hijacking homeostasis: Regulation of the tumor microenvironment by apoptosis
CD Gregory - Immunological reviews, 2023 - Wiley Online Library
Cancers are genetically driven, rogue tissues which generate dysfunctional, obdurate
organs by hijacking normal, homeostatic programs. Apoptosis is an evolutionarily conserved …
organs by hijacking normal, homeostatic programs. Apoptosis is an evolutionarily conserved …
Exploitation of apoptotic regulation in cancer
DS Ucker, JS Levine - Frontiers in immunology, 2018 - frontiersin.org
Within an organism, environmental stresses can trigger cell death, particularly apoptotic cell
death. Apoptotic cells, themselves, are potent regulators of their cellular environment …
death. Apoptotic cells, themselves, are potent regulators of their cellular environment …
Cell death in the tumor microenvironment: Implications for cancer immunotherapy
V Gadiyar, KC Lahey, D Calianese, C Devoe, D Mehta… - Cells, 2020 - mdpi.com
The physiological fate of cells that die by apoptosis is their prompt and efficient removal by
efferocytosis. During these processes, apoptotic cells release intracellular constituents that …
efferocytosis. During these processes, apoptotic cells release intracellular constituents that …
The apoptosis paradox in cancer
O Morana, W Wood, CD Gregory - International journal of molecular …, 2022 - mdpi.com
Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …
An apoptosis-driven 'onco-regenerative niche': roles of tumour-associated macrophages and extracellular vesicles
CD Gregory, M Paterson - Philosophical Transactions of …, 2018 - royalsocietypublishing.org
The cell-death programme, apoptosis, is well established as a tumour suppressor
mechanism. Paradoxically, high levels of apoptosis in tumours are closely coupled with poor …
mechanism. Paradoxically, high levels of apoptosis in tumours are closely coupled with poor …
[HTML][HTML] Role of the tumor microenvironment in tumor progression and the clinical applications
Y Yuan, YC Jiang, CK Sun… - Oncology reports, 2016 - spandidos-publications.com
Oncogene activation and tumor-suppressor gene inactivation are considered as the main
causes driving the transformation of normal somatic cells into malignant tumor cells. Cancer …
causes driving the transformation of normal somatic cells into malignant tumor cells. Cancer …
Clinical and biological implications of the tumor microenvironment
D Tarin - Cancer microenvironment, 2012 - Springer
In normal tissues and organs, the activities of the constituent cells are strictly restricted to the
tasks assigned to them during development. In addition they (with the exception of …
tasks assigned to them during development. In addition they (with the exception of …