Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional
cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy …

Although apoptosis is well recognized as a cell death program with clear anticancer roles,
accumulating evidence linking apoptosis with tissue repair and regeneration indicates that …

Here we consider the impact of the physiological cell‐death programme on normal tissue
homeostasis and on disease pathogenesis, with particular reference to evolution and …

Cancers are genetically driven, rogue tissues which generate dysfunctional, obdurate
organs by hijacking normal, homeostatic programs. Apoptosis is an evolutionarily conserved …

Within an organism, environmental stresses can trigger cell death, particularly apoptotic cell
death. Apoptotic cells, themselves, are potent regulators of their cellular environment …

The physiological fate of cells that die by apoptosis is their prompt and efficient removal by
efferocytosis. During these processes, apoptotic cells release intracellular constituents that …

Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

The cell-death programme, apoptosis, is well established as a tumour suppressor
mechanism. Paradoxically, high levels of apoptosis in tumours are closely coupled with poor …

Oncogene activation and tumor-suppressor gene inactivation are considered as the main
causes driving the transformation of normal somatic cells into malignant tumor cells. Cancer …

In normal tissues and organs, the activities of the constituent cells are strictly restricted to the
tasks assigned to them during development. In addition they (with the exception of …