Porphyrins and metalloporphyrins are the key pigments of life on earth as we know it,
because they include chlorophyll (a magnesium‐containing metalloporphyrin) and heme …

The hereditary porphyrias comprise a group of eight metabolic disorders of the heme
biosynthesis pathway. Each porphyria is caused by abnormal function at a separate …

Heme, like chlorophyll, is a primordial molecule and is one of the fundamental pigments of
life. Disorders of normal heme synthesis may cause human diseases, including certain …

The porphyrias comprise a set of diseases, each representing an individual defect in one of
the eight enzymes mediating the pathway of heme synthesis. The diseases are genetically …

The porphyrias are predominantly inherited metabolic disorders, which result from a specific
deficiency of one of the eight enzymes along the pathway of haem biosynthesis. Historically …

The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme
biosynthesis that present with episodic, acute neurovisceral symptoms. The four types are 5 …

The biosynthesis of porphyrins is one of the most conserved parthways known, about the
same sequence of reactions taking place in all species. By associating different metals …

The acute hepatic porphyrias include four disorders: acute intermittent porphyria [AIP],
hereditary coproporphyria [HCP], variegate porphyria [VP], and the rare porphyria due to …

Heme is an essential cofactor for most organisms and all metazoans. While the individual
enzymes involved in synthesis and utilization of heme are fairly well known, less is known …

The terminal three steps in haem biosynthesis are the oxidative decarboxylation of
coproporphyrinogen III to protoporphyrinogen IX, followed by the six-electron oxidation of …