Regeneration of actin filament branches from the same Arp2/3 complex
F Ghasemi, LY Cao, M Mladenov, B Guichard… - Science …, 2024 - science.org
Branched actin filaments are found in many key cellular structures. Branches are nucleated
by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to …
by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to …
[HTML][HTML] Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions
Actin branch junctions are conserved cytoskeletal elements critical for the generation of
protrusive force during actin polymerization-driven cellular motility. Assembly of actin branch …
protrusive force during actin polymerization-driven cellular motility. Assembly of actin branch …
Nucleation, stabilization, and disassembly of branched actin networks
AM Gautreau, FE Fregoso, G Simanov… - Trends in cell …, 2022 - cell.com
Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …
[HTML][HTML] Arp2/3 Branched Actin Network Mediates Filopodia-Like Bundles Formation In Vitro
Y Ideses, Y Brill-Karniely, L Haviv, A Ben-Shaul… - PloS one, 2008 - journals.plos.org
During cellular migration, regulated actin assembly takes place at the cell leading edge, with
continuous disassembly deeper in the cell interior. Actin polymerization at the plasma …
continuous disassembly deeper in the cell interior. Actin polymerization at the plasma …
Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches
NG Pandit, W Cao, J Bibeau… - Proceedings of the …, 2020 - National Acad Sciences
Networks of branched actin filaments formed by Arp2/3 complex generate and experience
mechanical forces during essential cellular functions, including cell motility and endocytosis …
mechanical forces during essential cellular functions, including cell motility and endocytosis …
[HTML][HTML] The stabilization of Arp2/3 complex generated actin filaments
The Arp2/3 complex, which generates both branched but also linear actin filaments via
activation of SPIN90, is evolutionarily conserved in eukaryotes. Several factors regulate the …
activation of SPIN90, is evolutionarily conserved in eukaryotes. Several factors regulate the …
[HTML][HTML] Molecular dynamics simulations support a multistep pathway for activation of branched actin filament nucleation by Arp2/3 complex
Actin-related protein 2/3 complex (Arp2/3 complex) catalyzes the nucleation of branched
actin filaments that push against membranes in processes like cellular motility and …
actin filaments that push against membranes in processes like cellular motility and …
Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy
B Ding, HY Narvaez-Ortiz, Y Singh… - Proceedings of the …, 2022 - National Acad Sciences
Arp2/3 complex nucleates branched actin filaments that provide pushing forces to drive
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …
Three‐dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors
XP Xu, I Rouiller, BD Slaughter, C Egile, E Kim… - The EMBO …, 2012 - embopress.org
Arp2/3 complex initiates the growth of branched actin‐filament networks by inducing actin
polymerization from the sides of pre‐existing filaments. Nucleation promoting factors (NPFs) …
polymerization from the sides of pre‐existing filaments. Nucleation promoting factors (NPFs) …
Regulation of branched versus linear Arp2/3‐generated actin filaments
Activation of the Arp2/3 complex by VCA‐motif‐bearing actin nucleation‐promoting factors
results in the formation of “daughter” actin filaments branching off the sides of pre‐existing …
results in the formation of “daughter” actin filaments branching off the sides of pre‐existing …