Genomics and signaling pathways in hepatocellular carcinoma

A Villanueva, P Newell, DY Chiang… - Seminars in liver …, 2007 - thieme-connect.com
Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients and
has become a major health problem in developed countries. There is an elemental …

Molecular pathogenesis of hepatocellular carcinoma

DWH Ho, RCL Lo, LK Chan, IOL Ng - Liver cancer, 2016 - karger.com
The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process involving the
progressive accumulation of molecular alterations pinpointing different molecular and …

[HTML][HTML] Cancer gene discovery in hepatocellular carcinoma

L Zender, A Villanueva, V Tovar, D Sia, DY Chiang… - Journal of …, 2010 - Elsevier
Hepatocellular carcinoma (HCC) is a deadly cancer, whose incidence is increasing
worldwide. Albeit the main risk factors for HCC development have been clearly identified …

[HTML][HTML] Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): an emerging field for advanced technologies

JU Marquardt, PR Galle, A Teufel - Journal of hepatology, 2012 - Elsevier
Despite great progress in diagnosis and management of hepatocellular carcinoma (HCC),
the exact biology of the tumor remains poorly understood overall limiting the patients' …

Molecular signaling pathways and therapeutic targets in hepatocellular carcinoma

M Dimri, A Satyanarayana - Cancers, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a complex biological process and is often diagnosed at
advanced stages with no effective treatment options. With advances in tumor biology and …

[HTML][HTML] The mutational landscape of hepatocellular carcinoma

JS Lee - Clinical and molecular hepatology, 2015 - ncbi.nlm.nih.gov
The development of hepatocellular carcinoma (HCC) is a complex process, and HCC arises
from the accumulation of multiple genetic alterations leading to changes in the genomic …

Liver cancer: molecular characterization, clonal evolution and cancer stem cells

G Castelli, E Pelosi, U Testa - Cancers, 2017 - mdpi.com
Liver cancer is the second most common cause of cancer-related death. The major forms of
primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic …

Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review

N Nishida, A Goel - Current genomics, 2011 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is the third most common cause of cancer deaths
worldwide, and the incidence of this fatal disease is still on rise. The majority of HCCs …

[PDF][PDF] WNT/β‐catenin signaling and hepatocellular carcinoma

JR Wands, M Kim - Hepatology, 2014 - Wiley Online Library
The pathogenesis of HCC involves a complex multistep process, which develops from a
normal hepatocyte or precursor cell type to a transformed phenotype due to the …

[HTML][HTML] Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy

C Chen, G Wang - World journal of hepatology, 2015 - ncbi.nlm.nih.gov
The incidence and mortality of hepatocellular carcinoma (HCC) have fallen dramatically in
China and elsewhere over the past several decades. Nonetheless, HCC remains a major …