[HTML][HTML] Therapeutic intervention in cancer by isoliquiritigenin from licorice: a natural antioxidant and redox regulator

Z Zhang, KKL Yung, JKS Ko - Antioxidants, 2022 - mdpi.com
Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration
and cancer, which are closely associated with intracellular signal transducers such as …

[HTML][HTML] Perspectives on the Role of Isoliquiritigenin in Cancer

KL Wang, YC Yu, SM Hsia - Cancers, 2021 - mdpi.com
Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …

[HTML][HTML] Dietary compound isoliquiritigenin, an antioxidant from licorice, suppresses triple-negative breast tumor growth via apoptotic death program activation in cell …

PH Lin, YF Chiang, TM Shieh, HY Chen, CK Shih… - Antioxidants, 2020 - mdpi.com
Patients with triple-negative breast cancer have few therapeutic strategy options. In this
study, we investigated the effect of isoliquiritigenin (ISL) on the proliferation of triple-negative …

Synthetic isoliquiritigenin inhibits human tongue squamous carcinoma cells through its antioxidant mechanism

C Hou, W Li, Z Li, J Gao, Z Chen, X Zhao… - Oxidative Medicine …, 2017 - Wiley Online Library
Isoliquiritigenin (ISL), a natural antioxidant, has antitumor activity in different types of cancer
cells. However the antitumor effect of ISL on human tongue squamous carcinoma cells …

Isoliquiritigenin inhibits proliferation and induces apoptosis via alleviating hypoxia and reducing glycolysis in mouse melanoma B16F10 cells

Y Wang, J Ma, X Yan, X Chen, L Si… - Recent patents on …, 2016 - ingentaconnect.com
Background: Isoliquiritigenin (ISL) is a licorice chalcone. According to CN104758274,
CN101658513 and US009089546, it is claimed that ISL has anti-inflammatory, anti …

A review: the pharmacology of isoliquiritigenin

F Peng, Q Du, C Peng, N Wang, H Tang… - Phytotherapy …, 2015 - Wiley Online Library
Isoliquiritigenin (ISL) is one of the bioactive ingredients isolated from the roots of plants
belonging to licorice, including Glycyrrhiza uralensis, Mongolian glycyrrhiza, Glycyrrhiza …

ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro

L Song, Y Luo, S Li, M Hong, Q Wang… - Drug Design …, 2020 - Taylor & Francis
Aims Isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, has previously been
reported to have anti-tumor effects in vivo and in vitro. However, the mechanisms whereby …

Isoliquiritigenin in licorice functions as a hepatic protectant by induction of antioxidant genes through extracellular signal-regulated kinase-mediated NF-E2-related …

SM Park, JR Lee, SK Ku, IJ Cho, SH Byun… - European journal of …, 2016 - Springer
Purpose Liver is the major site of biotransformation for exogenous toxins, in having a
defense system against oxidative stress as well as cytochrome P450 system. Isoliquiritigenin …

Isoliquiritigenin inhibits pancreatic cancer progression through blockade of p38 MAPK-regulated autophagy

Z Zhang, W Chen, S Zhang, J Bai, B Liu, KKL Yung… - Phytomedicine, 2022 - Elsevier
Background Pancreatic cancer has been characterized by poor prognosis, early metastasis
and dissatisfactory treatment outcome. The high basal level of autophagy in tumor cells …

[HTML][HTML] Isoliquiritigenin induces autophagy and inhibits ovarian cancer cell growth

HY Chen, TC Huang, TM Shieh, CH Wu, LC Lin… - International journal of …, 2017 - mdpi.com
Ovarian cancer is one of the commonest gynecologic malignancies, which has a poor
prognosis for patients at the advanced stage. Isoliquiritigenin (ISL), an active flavonoid …