Major depressive disorder (MDD) is an often chronic and/or recurrent disorder that is
associated with dysfunctions in multiple aspects of life including work and non-workrelated …

One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …

Treatment-resistant depression (TRD) is a growing area of discussion among researchers
and medical professionals. Varying resistance levels among patients with TRD pose …

Depressive episodes that do not respond to at least several adequate courses of standard
antidepressants account for a substantial proportion of the socioeconomic and medical …

Dr. Janicak has disclosed that he is/was the recipient of grant/research support from Bristol-
Meyers Squibb/Otsuka, Janssen, and Neuronetics; is/was a consultant/advisor to Bristol …

In simplest terms, resistance is best thought of using an analogy from medical microbiology;
6 namely, that an episode of illness has not responded to one or more specific types or …

Only 50% of depressed patients achieve remission of symptoms after 2 trials of
antidepressants. Therefore one half of patients are considered treatment resistant. Studies …

Canada and a lifetime prevalence of 8%. 1 The human cost of the illness in terms of
impaired social and emotional functioning cannot be emphasized enough, and the societal …

Major depression is a commonly encountered mental disorder in clinical practice. Although
choices of antidepressant drugs appear to be many, all current antidepressant drugs have …

The burden of major depressive disorder is huge, as is clearly documented by World Health
Organization data. A major component of this burden is the episodic nature of depression …