Context: Determining the etiology of delayed puberty during initial evaluation can be
challenging. Specifically, clinicians often cannot distinguish constitutional delay of growth …

Objective The distinction between constitutional delay of growth and puberty (CDGP) and
isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but …

In pre‐pubertal boys≥ 14 years, the differentiation between constitutional delay of growth
and puberty (CDGP) and hypogonadotropic hypogonadism (HH) is challenging, as current …

Background: Delayed puberty can be due to either constitutional delay of growth and
puberty (CDGP) or hypogonadotropic hypogonadism (HH). Differentiating between the two …

Context: The diagnosis of isolated hypogonadotropic hypogonadism (IHH) in boys with
delayed puberty is challenging, as may be the diagnosis of hypogonadotropic …

Objective The effectiveness of biological investigations aiming at discriminating isolated
hypogonadotropic hypogonadism (IHH) from constitutional delayed puberty (CDP) in male …

STUDY QUESTION What diagnoses underlie delayed puberty (DP) and predict its outcome?
SUMMARY ANSWER A multitude of different diagnoses underlie DP, and in boys a history …

Context: Differential diagnosis between hypogonadotropic hypogonadism (HH) and
constitutional delay of puberty in boys is challenging. Most tests use an acute GnRH …

Delayed puberty (DP) affects approximately 2% of adolescents. In the vast majority of
patients in both sexes, it is due to constitutional delay of growth and puberty (CDGP), a self …

Delayed puberty (DP) is defined as the lack of pubertal development by an age that is 2–2.5
SDs beyond the population mean. Although it generally represents a normal variant in …