This review focuses on the use of synthetic (non-viral) delivery systems for cancer gene
therapy. Therapeutic strategies such as gene replacement/mutation correction, immune …

Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its
potential role in the treatment of acquired diseases such as cancer is now widely …

Targeting therapeutic genes to tumors is an attractive concept in curing malignant diseases.
Systemic gene delivery systems are needed for therapeutic applications in which the target …

Gene therapy is part of a growing field in molecular medicine, which will gain importance in
the treatment of human diseases. Until now, almost two thirds of all clinical trials performed …

Although synthetic vectors have generally been considered to be less efficient than their
viral counterparts, a recent study suggests that the intrinsic anti-tumour activity of some …

Gene therapy for cancer treatment represents a promising approach that has shown
selectivity and efficacy in experimental systems as well as clinical trials. Some major …

[Frontiers in Biosciecne 3, d1161-1170, November 15, 1998] 1161 TARGETED, NON-VIRAL
GENE DELIVERY FOR CANCER GENE THERAPY Richar Page 1 [Frontiers in Biosciecne 3 …

Nucleic acids offer the possibility of tailor-made, individualized treatments for genetic
disorders, infectious diseases, and cancer. As an alternative to viral vectors, synthetic …

Lack of selectivity together with severe side effects in conventional cancer treatment have
afforded the development of new strategies based on gene therapy. Nowadays, gene …

The burden of cancer is increasing globally. Several challenges facing its mainstream
treatment approaches have formed the basis for the development of targeted delivery …