Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
K Yamamoto, A Venida, J Yano, DE Biancur… - Nature, 2020 - nature.com
Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion
include impaired antigen presentation caused by mutations or loss of heterozygosity of the …
include impaired antigen presentation caused by mutations or loss of heterozygosity of the …
Selective autophagy of MHC-I promotes immune evasion of pancreatic cancer
K Yamamoto, A Venida, RM Perera, AC Kimmelman - Autophagy, 2020 - Taylor & Francis
Major histocompatibility complex class I (MHC-I) is a key molecule in anti-tumor adaptive
immunity. MHC-I is essential for endogenous antigen presentation by cancer cells and …
immunity. MHC-I is essential for endogenous antigen presentation by cancer cells and …
p53 status determines the role of autophagy in pancreatic tumour development
MT Rosenfeldt, J O'Prey, JP Morton, C Nixon… - Nature, 2013 - nature.com
Macroautophagy (hereafter referred to as autophagy) is a process in which organelles
termed autophagosomes deliver cytoplasmic constituents to lysosomes for degradation …
termed autophagosomes deliver cytoplasmic constituents to lysosomes for degradation …
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice
M Michaud, I Martins, AQ Sukkurwala, S Adjemian… - Science, 2011 - science.org
Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell
death, thus provoking an anticancer immune response. Here we demonstrate that …
death, thus provoking an anticancer immune response. Here we demonstrate that …
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
L Poillet-Perez, DW Sharp, Y Yang, SV Laddha… - Nature cancer, 2020 - nature.com
Macroautophagy (hereafter autophagy) degrades and recycles intracellular components to
sustain metabolism and survival during starvation. Host autophagy promotes tumor growth …
sustain metabolism and survival during starvation. Host autophagy promotes tumor growth …
γδ T cells are effectors of immunotherapy in cancers with HLA class I defects
DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that
is thought to explain their exceptional responsiveness to immune checkpoint blockade …
is thought to explain their exceptional responsiveness to immune checkpoint blockade …
Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is considered non-immunogenic, with trials
showing its recalcitrance to PD1 and CTLA4 immune checkpoint therapies (ICTs). Here, we …
showing its recalcitrance to PD1 and CTLA4 immune checkpoint therapies (ICTs). Here, we …
MHC-II neoantigens shape tumour immunity and response to immunotherapy
E Alspach, DM Lussier, AP Miceli, I Kizhvatov… - Nature, 2019 - nature.com
The ability of the immune system to eliminate and shape the immunogenicity of tumours
defines the process of cancer immunoediting. Immunotherapies such as those that target …
defines the process of cancer immunoediting. Immunotherapies such as those that target …
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with
pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of a …
pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of a …
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
JL Guerriero, A Sotayo, HE Ponichtera, JA Castrillon… - Nature, 2017 - nature.com
Although the main focus of immuno-oncology has been manipulating the adaptive immune
system, harnessing both the innate and adaptive arms of the immune system might produce …
system, harnessing both the innate and adaptive arms of the immune system might produce …
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