Increased Circulating CD62E+ Endothelial Extracellular Vesicles Predict Severity and in- Hospital Mortality of COVID-19 Patients

F Mezine, CL Guerin, A Philippe, N Gendron… - Stem Cell Reviews and …, 2023 - Springer
COVID-19 and infectious diseases have been included in strategic development goals
(SDG) of United Nations (UN). Severe form of COVID-19 has been described as an …

Longitudinal trend of plasma concentrations of extracellular vesicles in patients hospitalized for COVID-19

E Campello, CM Radu, C Simion, L Spiezia… - Frontiers in Cell and …, 2022 - frontiersin.org
Plasma concentrations of extracellular vesicles (EVs) originating from cells involved in
COVID-19-associated coagulopathy (CAC), their longitudinal trend and association with …

[HTML][HTML] The potential role of extracellular vesicles in COVID-19 associated endothelial injury and pro-inflammation

B Krishnamachary, C Cook, L Spikes, P Chalise… - medRxiv, 2020 - ncbi.nlm.nih.gov
COVID-19 infection caused by the novel severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) has resulted in a global pandemic with the number of deaths growing …

Extracellular vesicles of COVID-19 patients reflect inflammation, thrombogenicity, and disease severity

A Aharon, A Dangot, F Kinaani, M Zavaro… - International Journal of …, 2023 - mdpi.com
Severe COVID-19 infections present with cytokine storms, hypercoagulation, and acute
respiratory distress syndrome, with extracellular vesicles (EVs) being involved in …

ICU admission levels of endothelial biomarkers as predictors of mortality in critically ill COVID-19 patients

AG Vassiliou, C Keskinidou, E Jahaj, P Gallos… - Cells, 2021 - mdpi.com
Endotheliopathy is suggested to be an important feature of COVID-19 in hospitalized
patients. To determine whether endotheliopathy is involved in COVID-19-associated …

Extracellular vesicle‐mediated endothelial apoptosis and EV‐associated proteins correlate with COVID‐19 disease severity

B Krishnamachary, C Cook, A Kumar… - Journal of …, 2021 - Wiley Online Library
Abstract Coronavirus disease‐2019 (COVID‐19), caused by the novel severe acute
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), has lead to a global pandemic with a …

Circulating endothelial cells as a marker of endothelial injury in severe COVID-19

C Guervilly, S Burtey, F Sabatier… - The Journal of …, 2020 - academic.oup.com
Beside the commonly described pulmonary expression of the coronavirus disease 2019
(COVID-19), major vascular events have been reported. The objective of this study was to …

The significance of phenotyping and quantification of plasma extracellular vesicles levels using high-sensitivity flow cytometry during COVID-19 treatment

I Kudryavtsev, O Kalinina, V Bezrukikh, O Melnik… - Viruses, 2021 - mdpi.com
New investigation results point to the potential participation of extracellular vesicles (EVs) in
the pathogenesis of coronavirus infection, its progression, and mechanisms of the therapy …

Extracellular vesicle features are associated with COVID‐19 severity

F Caponnetto, M De Martino… - Journal of Cellular …, 2023 - Wiley Online Library
Abstract COVID‐19 is heterogeneous; therefore, it is crucial to identify early biomarkers for
adverse outcomes. Extracellular vesicles (EV) are involved in the pathophysiology of COVID …

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

S Pons, S Fodil, E Azoulay, L Zafrani - Critical care, 2020 - Springer
In severe SARS-CoV-2 infections, emerging data including recent histopathological studies
have emphasized the crucial role of endothelial cells (ECs) in vascular dysfunction …