The prefrontal cortex (PFC) is a cortical brain region that regulates various cognitive
functions. One distinctive feature of the PFC is its protracted adolescent maturation, which is …

Most cognitive functions involving the prefrontal cortex emerge during late development.
Increasing evidence links this delayed maturation to the protracted timeline of prefrontal …

Innate immune cells play a well-documented role in the etiology and disease course of
many brain-based conditions, including multiple sclerosis, Alzheimer's disease, traumatic …

Disturbed neuronal activity in neuropsychiatric pathologies emerges during development
and might cause multifold neuronal dysfunction by interfering with apoptosis, dendritic …

One major function of our brain is to enable us to behave with respect to socially relevant
information. Much research on how the adult human brain processes the social world has …

The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

Dysfunction of microglia, the tissue macrophages of the brain, has been associated with the
etiology of several neuropsychiatric disorders. Consistently, microglia have been shown to …

During brain development, the generation of neurons and glial cells is rigorously regulated
by diverse mechanisms including the immune system. Dysfunction of the developing system …

Juvenile social experience is crucial for the functional development of forebrain regions,
especially the prefrontal cortex (PFC). We previously reported that social isolation for 2 …

Cross-talk between the nervous and immune systems has been well described in the
context of adult physiology and disease. Recent advances in our understanding of immune …