Development of antiviral agents for enteroviruses

TC Chen, KF Weng, SC Chang, JY Lin… - Journal of …, 2008 - academic.oup.com
Enteroviruses (EVs) are common human pathogens that are associated with numerous
disease symptoms in many organ systems of the body. Although EV infections commonly …

Combating enterovirus replication: state-of-the-art on antiviral research

HJ Thibaut, AM De Palma, J Neyts - Biochemical pharmacology, 2012 - Elsevier
Enteroviruses form an important genus within the large family of Picornaviridae. They are
small, non-enveloped (+) RNA viruses, many of which are important pathogens in human …

Antivirals blocking entry of enteroviruses and therapeutic potential

MI Anasir, F Zarif, CL Poh - Journal of Biomedical Science, 2021 - Springer
Viruses from the genus Enterovirus (EV) of the Picornaviridae family are known to cause
diseases such as hand foot and mouth disease (HFMD), respiratory diseases, encephalitis …

[HTML][HTML] Direct-acting antivirals and host-targeting strategies to combat enterovirus infections

L Bauer, H Lyoo, HM van der Schaar… - Current opinion in …, 2017 - Elsevier
Highlights•Enteroviruses cause many human diseases, yet no antiviral drugs are
available.•Capsids and viral enzymes are promising targets for direct-acting antiviral …

Direct-acting antivirals and host-targeting approaches against enterovirus B infections: recent advances

C Tammaro, M Guida, F Appetecchia, M Biava… - Pharmaceuticals, 2023 - mdpi.com
Enterovirus B (EV-B)-related diseases, which can be life threatening in high-risk
populations, have been recognized as a serious health problem, but their clinical treatment …

The efficacy of viral capsid inhibitors in human enterovirus infection and associated diseases

C Li, H Wang, SR Shih, TC Chen… - Current medicinal …, 2007 - ingentaconnect.com
Enteroviruses are members of picornavirus family which causes diverse and severe
diseases in humans and animals. Clinical manifestations of enterovirus infections include …

Enteroviruses: The role of receptors in viral pathogenesis

E Heckenberg, JT Steppe, CB Coyne - Advances in Virus Research, 2022 - Elsevier
Enteroviruses are among the most common viral infectious agents of humans and cause a
broad spectrum of illness, which can range from mild and self-limiting to severe. Severe …

The life cycle of non-polio enteroviruses and how to target it

J Baggen, HJ Thibaut, JRPM Strating… - Nature Reviews …, 2018 - nature.com
The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus,
coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse …

The pyrimidine analog FNC potently inhibits the replication of multiple enteroviruses

N Xu, J Yang, B Zheng, Y Zhang, Y Cao… - Journal of …, 2020 - Am Soc Microbiol
Human enteroviruses (EVs), including coxsackieviruses, the numbered enteroviruses, and
echoviruses, cause a wide range of diseases, such as hand, foot, and mouth disease …

Screening of a library of FDA-approved drugs identifies several enterovirus replication inhibitors that target viral protein 2C

R Ulferts, SM De Boer, L van Der Linden… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Enteroviruses (EVs) represent many important pathogens of humans. Unfortunately, no
antiviral compounds currently exist to treat infections with these viruses. We screened the …