Roles for the endoplasmic reticulum in regulation of neuronal calcium homeostasis

NE Karagas, K Venkatachalam - Cells, 2019 - mdpi.com
By influencing Ca2+ homeostasis in spatially and architecturally distinct neuronal
compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function …

Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons

A Verkhratsky - Physiological reviews, 2005 - journals.physiology.org
The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

MP Mattson, FM LaFerla, SL Chan, MA Leissring… - Trends in …, 2000 - cell.com
Endoplasmic reticulum (ER) is a multifaceted organelle that regulates protein synthesis and
trafficking, cellular responses to stress, and intracellular Ca 2+ levels. In neurons, it is …

Endoplasmic reticulum Ca2+ homeostasis and neuronal death

A Verkhratsky, EC Toescu - Journal of cellular and molecular …, 2003 - Wiley Online Library
The endoplasmic reticulum (ER) is a universal signalling organelle, which regulates a wide
range of neuronal functional responses. Calcium release from the ER underlies various …

The endoplasmic reticulum and neuronal calcium signalling

A Verkhratsky - Cell calcium, 2002 - Elsevier
The endoplasmic reticulum (ER) is a multifunctional signalling organelle regulating a wide
range of neuronal functional responses. The ER is intimately involved in intracellular Ca2+ …

Pharmacological regulation of endoplasmic reticulum structure and calcium dynamics: importance for neurodegenerative diseases

I Parkkinen, A Their, MY Asghar, S Sree… - Pharmacological …, 2023 - ASPET
The endoplasmic reticulum (ER) is the largest organelle of the cell, composed of a
continuous network of sheets and tubules, and is involved in protein, calcium (Ca2+), and …

Endoplasmic reticulum calcium signaling in nerve cells

A Verkhratsky - Biological research, 2004 - SciELO Chile
The endoplasmic reticulum (ER) is an important organelle involved in various types of
signaling in nerve cells. The ER serves as a dynamic Ca2+ pool being thus involved in rapid …

Role of the endoplasmic reticulum in synaptic transmission

NL Chanaday, ET Kavalali - Current opinion in neurobiology, 2022 - Elsevier
Neurons possess a complex morphology spanning long distances and a large number of
subcellular specializations such as presynaptic terminals and dendritic spines. This …

Luminal transport through intact endoplasmic reticulum limits the magnitude of localized Ca2+ signals

CC Crapart, ZC Scott, T Konno… - Proceedings of the …, 2024 - National Acad Sciences
The endoplasmic reticulum (ER) forms an interconnected network of tubules stretching
throughout the cell. Understanding how ER functionality relies on its structural organization …

Endoplasmic reticulum Ca2+ handling in excitable cells in health and disease

GE Stutzmann, MP Mattson - Pharmacological reviews, 2011 - ASPET
The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle
capable of integrating multiple extracellular and internal signals and generating adaptive …