The role of Interleukin 1 receptor antagonist in mesenchymal stem cell‐based tissue repair and regeneration

CR Harrell, BS Markovic, C Fellabaum… - Biofactors, 2020 - Wiley Online Library
Abstract Interleukin (IL)‐1 receptor antagonist (IL‐1Ra), a naturally occurring antagonist of IL‐
1α/IL‐1β signaling pathways, has been attributed to the immunosuppressive effects of …

Mesenchymal stem cell-derived interleukin 1 receptor antagonist promotes macrophage polarization and inhibits B cell differentiation

P Luz-Crawford, F Djouad, K Toupet, C Bony… - Stem Cells, 2016 - academic.oup.com
The role of interleukin 1 receptor antagonist (IL1RA) in mediating the immunosuppressive
effect of mesenchymal stem/stromal cells (MSCs) has been reported in several studies …

Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury

LA Ortiz, M DuTreil, C Fattman… - Proceedings of the …, 2007 - National Acad Sciences
Mesenchymal stem cells (MSCs) have been exploited as cellular vectors to treat a wide
array of diseases but the mechanisms responsible for their therapeutic effect remain …

Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10

SH Yang, MJ Park, IH Yoon, SY Kim, SH Hong… - … & molecular medicine, 2009 - nature.com
Mesenchymal stem cells (MSCs) can inhibit T cell proliferation; however, the underlying
mechanisms are not clear. In this study, we investigated the mechanisms of the …

Interleukin-10-overexpressing mesenchymal stromal cells induce a series of regulatory effects in the inflammatory system and promote the survival of endotoxin …

C Wang, D Lv, X Zhang, Z Ni, X Sun, C Zhu - DNA and cell biology, 2018 - liebertpub.com
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
inflammatory conditions with no effective pharmacological treatment. Previous studies …

Concise review: mesenchymal stem cells and translational medicine: emerging issues

G Ren, X Chen, F Dong, W Li, X Ren… - Stem cells …, 2012 - academic.oup.com
Mesenchymal stem cells (MSCs) are emerging as a promising therapeutic approach of cell-
based therapy for a wide range of autoimmune disorders and degenerative diseases. In …

The interaction between mesenchymal stem cells and steroids during inflammation

X Chen, Y Gan, W Li, J Su, Y Zhang, Y Huang… - Cell death & …, 2014 - nature.com
Mesenchymal stem cells (MSCs) are believed to exert their regenerative effects through
differentiation and modulation of inflammatory responses. However, the relationship …

IL‐10 gene‐modified human amniotic mesenchymal stem cells augment regenerative wound healing by multiple synergistic effects

S Xiao, G Huang, Z Wei, K Nie, Z Liu… - Stem Cells …, 2019 - Wiley Online Library
Mesenchymal stem cells (MSCs) possess a capacity to enhance cutaneous wound healing
that is well characterized. However, the therapeutic effect of MSCs appears to be limited …

Interleukin (IL)-10 Induced by CD11b+ Cells and IL-10-Activated Regulatory T Cells Play a Role in Immune Modulation of Mesenchymal Stem Cells in Rat Islet …

YH Kim, YM Wee, MY Choi, DG Lim, SC Kim… - Molecular Medicine, 2011 - Springer
Mesenchymal stem cells (MSCs) are suggested to be immune modulators because of their
therapeutic potential in transplantation. In the present study, we evaluated the therapeutic …

Mesenchymal stem cells attenuate liver fibrosis by suppressing Th17 cells–an experimental study

N Milosavljevic, M Gazdic… - Transplant …, 2018 - Wiley Online Library
This study investigates molecular and cellular mechanisms involved in mesenchymal stem
cell (MSC)‐mediated modulation of IL‐17 signaling during liver fibrosis. Mice received CC l4 …