RETRACTED ARTICLE: Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling

Y Yao, C Li, F Qian, Y Zhao, X Shi, D Hong… - Journal of …, 2021 - Taylor & Francis
Yao Y, Li C, Qian F, et al. J Inflamm Res. 2021; 14: 6619–6632. The Editor and Publisher of
the Journal of Inflammation Research are retracting the published article. The authors …

Gastrodin attenuates lipopolysaccharide-induced inflammatory response and migration via the Notch-1 signaling pathway in activated microglia

Y Yao, R Li, Y Guo, Y Zhao, J Guo, Q Ai, L Zhong… - NeuroMolecular …, 2022 - Springer
Microglia-mediated neuroinflammation is known to play a pivotal role in the pathogenesis of
different neurological diseases. Gastrodin, a phenolic glucoside, has been reported to exert …

Gastrodin inhibits inflammasome through the STAT3 signal pathways in TNA2 astrocytes and reactive astrocytes in experimentally induced cerebral ischemia in rats

Y Sui, L Bian, Q Ai, Y Yao, M Yu, H Gao, A Zhang… - NeuroMolecular …, 2019 - Springer
This study was aimed to determine Gastrodin (GAS) and its underlying signaling pathway
involved in suppression of inflammasome specifically in reactive astrocytes that are featured …

Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p

JJ Song, H Li, N Wang, XY Zhou, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Background: Neuroinflammation plays a pivotal role in the pathogenesis of Central Nervous
System (CNS) diseases. The phenolic glucoside gastrodin (GAS), has been known to treat …

Anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells

YY Lee, JS Park, JS Jung, DH Kim, HS Kim - International journal of …, 2013 - mdpi.com
Microglia are resident immune cells in the central nervous system. They play a role in
normal brain development and neuronal recovery. However, overactivation of microglia …

Ginsenoside Rg1 treats ischemic stroke by regulating CKLF1/CCR5 axis-induced neuronal cell pyroptosis

J Long, Y Sun, S Liu, C Chen, Q Yan, Y Lin, Z Zhang… - Phytomedicine, 2024 - Elsevier
Background Ischemic stroke, a severe and life-threatening neurodegenerative condition,
currently relies on thrombolytic therapy with limited therapeutic window and potential risks of …

Ginsenoside compound K acts via LRP1 to alleviate Amyloid β42-induced neuroinflammation in microglia by suppressing NF-κB

H Jiao, J Jia - Biochemical and Biophysical Research …, 2022 - Elsevier
Background Alzheimer's disease (AD), has caused a mass of disability and mortality in elder
populations, which increases global health burden. There are still limited effective disease …

[HTML][HTML] Gastrodin suppresses pyroptosis and exerts neuroprotective effect in traumatic brain injury model by inhibiting NLRP3 inflammasome signaling pathway

F Yang, G Li, B Lin, K Zhang - Journal of Integrative Neuroscience, 2022 - imrpress.com
Traumatic brain injury (TBI), also known as head injury or brain injury, refers to the head
injury caused by mechanical impact. It is necessary to develop effective new therapies for …

Korean red ginseng saponins play an anti-inflammatory role by targeting caspase-11 non-canonical inflammasome in macrophages

HJ Cho, E Kim, YS Yi - International Journal of Molecular Sciences, 2023 - mdpi.com
We previously reported that Korean red ginseng (KRG) exerts an anti-inflammatory role
through inhibiting caspase-11 non-canonical inflammasome in macrophages; however, the …

Protective effect of ginsenoside Rh2 against Toxoplasma gondii infection-induced neuronal injury through binding TgCDPK1 and NLRP3 to inhibit microglial NLRP3 …

GN Jin, JM Lu, HW Lan, YN Lu, XY Shen, X Xu… - International …, 2022 - Elsevier
Background Toxoplasma gondii (T. gondii) is a neurotropic obligate intracellular parasite
that can activate microglial and promote neuronal apoptosis, leading to central nervous …