An RNA-hydrolyzing recombinant minibody prevents both influenza A virus and coronavirus in co-infection models
QXT Luong, PT Hoang, Y Lee, RQ Ayun, K Na… - Scientific Reports, 2024 - nature.com
With the lifting of COVID-19 non-pharmaceutical interventions, the resurgence of common
viral respiratory infections was recorded in several countries worldwide. It facilitates viral co …
viral respiratory infections was recorded in several countries worldwide. It facilitates viral co …
A Therapeutically Active Minibody Exhibits an Antiviral Activity in Oseltamivir-Resistant Influenza-Infected Mice via Direct Hydrolysis of Viral RNAs
Y Lee, PT Hoang, D Kim, RQ Ayun, QXT Luong, K Na… - Viruses, 2022 - mdpi.com
Emerging Oseltamivir-resistant influenza strains pose a critical public health threat due to
antigenic shifts and drifts. We report an innovative strategy for controlling influenza A …
antigenic shifts and drifts. We report an innovative strategy for controlling influenza A …
A synergistic therapy against influenza virus A/H1N1/PR8 by a HA1 specific neutralizing single-domain VL and an RNA hydrolyzing scFv
PT Hoang, QXT Luong, RQ Ayun, Y Lee… - Frontiers in …, 2024 - frontiersin.org
The emergence of anti-influenza drug-resistant strains poses a challenge for influenza
therapy due to mutations in the virus's surface protein. Recently, there has been increasing …
therapy due to mutations in the virus's surface protein. Recently, there has been increasing …
Broad-spectrum antiviral activity of 3D8, a nucleic acid-hydrolyzing single-chain variable fragment (scFv), targeting SARS-CoV-2 and multiple coronaviruses in vitro
G Lee, S Budhathoki, GY Lee, K Oh, YK Ham, YJ Kim… - Viruses, 2021 - mdpi.com
The virus behind the current pandemic, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is responsible for the etiology of novel coronavirus disease (COVID-19) and …
(SARS-CoV-2) is responsible for the etiology of novel coronavirus disease (COVID-19) and …
A live attenuated vaccine prevents replication and transmission of H7N9 highly pathogenic influenza viruses in mammals
H7N9 influenza viruses emerged in 2013 and have caused severe disease and deaths in
humans in China. Some H7N9 viruses circulating in chickens have mutated to highly …
humans in China. Some H7N9 viruses circulating in chickens have mutated to highly …
[PDF][PDF] Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice
H Liu, L Wu, B Liu, K Xu, W Lei, J Deng, X Rong… - Cell Reports …, 2023 - cell.com
With the widespread vaccinations against coronavirus disease 2019 (COVID-19), we are
witnessing gradually waning neutralizing antibodies and increasing cases of breakthrough …
witnessing gradually waning neutralizing antibodies and increasing cases of breakthrough …
Proof-of-concept for effective antiviral activity of an in silico designed decoy synthetic mRNA against SARS-CoV-2 in the Vero E6 cell-based infection model
N Atari, O Erster, YH Shteinberg, H Asraf… - Frontiers in …, 2023 - frontiersin.org
The positive-sense single-stranded (ss) RNA viruses of the Betacoronavirus (beta-CoV)
genus can spillover from mammals to humans and are an ongoing threat to global health …
genus can spillover from mammals to humans and are an ongoing threat to global health …
Preventive Activity against Influenza (H1N1) Virus by intranasally delivered RNA-hydrolyzing antibody in respiratory epithelial cells of mice
The antiviral effect of a catalytic RNA-hydrolyzing antibody, 3D8 scFv, for intranasal
administration against avian influenza virus (H1N1) was described. The recombinant 3D8 …
administration against avian influenza virus (H1N1) was described. The recombinant 3D8 …
Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster
YN Zhang, HQ Zhang, GF Wang, ZR Zhang, JQ Li… - Antiviral Research, 2023 - Elsevier
The Omicron variant is sweeping the world, which displays striking immune escape potential
through mutations at key antigenic sites on the spike protein, making broad-spectrum SARS …
through mutations at key antigenic sites on the spike protein, making broad-spectrum SARS …
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal …
H Ma, X Zhang, W Zeng, J Zhou, X Chi, S Chen… - Cell Discovery, 2022 - nature.com
Abstract Current SARS-CoV-2 Omicron subvariants impose a heavy burden on global health
systems by evading immunity from most developed neutralizing antibodies and vaccines …
systems by evading immunity from most developed neutralizing antibodies and vaccines …