An RNA-hydrolyzing recombinant minibody prevents both influenza A virus and coronavirus in co-infection models

QXT Luong, PT Hoang, Y Lee, RQ Ayun, K Na… - Scientific Reports, 2024 - nature.com
With the lifting of COVID-19 non-pharmaceutical interventions, the resurgence of common
viral respiratory infections was recorded in several countries worldwide. It facilitates viral co …

A Therapeutically Active Minibody Exhibits an Antiviral Activity in Oseltamivir-Resistant Influenza-Infected Mice via Direct Hydrolysis of Viral RNAs

Y Lee, PT Hoang, D Kim, RQ Ayun, QXT Luong, K Na… - Viruses, 2022 - mdpi.com
Emerging Oseltamivir-resistant influenza strains pose a critical public health threat due to
antigenic shifts and drifts. We report an innovative strategy for controlling influenza A …

A synergistic therapy against influenza virus A/H1N1/PR8 by a HA1 specific neutralizing single-domain VL and an RNA hydrolyzing scFv

PT Hoang, QXT Luong, RQ Ayun, Y Lee… - Frontiers in …, 2024 - frontiersin.org
The emergence of anti-influenza drug-resistant strains poses a challenge for influenza
therapy due to mutations in the virus's surface protein. Recently, there has been increasing …

Broad-spectrum antiviral activity of 3D8, a nucleic acid-hydrolyzing single-chain variable fragment (scFv), targeting SARS-CoV-2 and multiple coronaviruses in vitro

G Lee, S Budhathoki, GY Lee, K Oh, YK Ham, YJ Kim… - Viruses, 2021 - mdpi.com
The virus behind the current pandemic, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is responsible for the etiology of novel coronavirus disease (COVID-19) and …

A live attenuated vaccine prevents replication and transmission of H7N9 highly pathogenic influenza viruses in mammals

W Yang, X Yin, L Guan, M Li, S Ma, J Shi… - Emerging Microbes & …, 2018 - Taylor & Francis
H7N9 influenza viruses emerged in 2013 and have caused severe disease and deaths in
humans in China. Some H7N9 viruses circulating in chickens have mutated to highly …

[PDF][PDF] Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice

H Liu, L Wu, B Liu, K Xu, W Lei, J Deng, X Rong… - Cell Reports …, 2023 - cell.com
With the widespread vaccinations against coronavirus disease 2019 (COVID-19), we are
witnessing gradually waning neutralizing antibodies and increasing cases of breakthrough …

Proof-of-concept for effective antiviral activity of an in silico designed decoy synthetic mRNA against SARS-CoV-2 in the Vero E6 cell-based infection model

N Atari, O Erster, YH Shteinberg, H Asraf… - Frontiers in …, 2023 - frontiersin.org
The positive-sense single-stranded (ss) RNA viruses of the Betacoronavirus (beta-CoV)
genus can spillover from mammals to humans and are an ongoing threat to global health …

Preventive Activity against Influenza (H1N1) Virus by intranasally delivered RNA-hydrolyzing antibody in respiratory epithelial cells of mice

S Cho, HN Youn, PM Hoang, S Cho, KE Kim, EJ Kil… - Viruses, 2015 - mdpi.com
The antiviral effect of a catalytic RNA-hydrolyzing antibody, 3D8 scFv, for intranasal
administration against avian influenza virus (H1N1) was described. The recombinant 3D8 …

Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster

YN Zhang, HQ Zhang, GF Wang, ZR Zhang, JQ Li… - Antiviral Research, 2023 - Elsevier
The Omicron variant is sweeping the world, which displays striking immune escape potential
through mutations at key antigenic sites on the spike protein, making broad-spectrum SARS …

A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal …

H Ma, X Zhang, W Zeng, J Zhou, X Chi, S Chen… - Cell Discovery, 2022 - nature.com
Abstract Current SARS-CoV-2 Omicron subvariants impose a heavy burden on global health
systems by evading immunity from most developed neutralizing antibodies and vaccines …