A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics
The rapid repurposing of antivirals is particularly pressing during pandemics. However,
rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines …
rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines …
[PDF][PDF] Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics
Rapidly spreading viral pandemics, such as those caused by influenza and SAR-CoV-2
(COVID19), require rapid action and the fastest way to combat this challenge is by …
(COVID19), require rapid action and the fastest way to combat this challenge is by …
High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro
AL Gard, RJ Luu, CR Miller, R Maloney, BP Cain… - Scientific reports, 2021 - nature.com
Influenza and other respiratory viruses present a significant threat to public health, national
security, and the world economy, and can lead to the emergence of global pandemics such …
security, and the world economy, and can lead to the emergence of global pandemics such …
Microfluidic organs-on-a-chip for modeling human infectious diseases
Conspectus Infectious diseases present tremendous challenges to human progress and
public health. The emergence of severe acute respiratory syndrome coronavirus 2 (SARS …
public health. The emergence of severe acute respiratory syndrome coronavirus 2 (SARS …
Development of human-derived, three-dimensional respiratory epithelial tissue constructs with perfusable microvasculature on a high-throughput microfluidics …
O Jung, YT Tung, E Sim, YC Chen, E Lee… - …, 2022 - iopscience.iop.org
The COVID-19 pandemic has highlighted the need for human respiratory tract-based assay
platforms for efficient discovery and development of antivirals and disease-modulating …
platforms for efficient discovery and development of antivirals and disease-modulating …
[PDF][PDF] SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming
How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …
Microfluidic organ-chips and stem cell models in the fight against COVID-19
S Satta, SJ Rockwood, K Wang, S Wang… - Circulation …, 2023 - Am Heart Assoc
SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause
multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 …
multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 …
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes
There are currently limited Food and Drug Administration (FDA)-approved drugs and
vaccines for the treatment or prevention of Coronavirus Disease 2019 (COVID-19) …
vaccines for the treatment or prevention of Coronavirus Disease 2019 (COVID-19) …
In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease
N Heinen, M Klöhn, E Steinmann, S Pfaender - Viruses, 2021 - mdpi.com
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has
put scientist and pharmaceutical companies worldwide on the spot to develop novel …
put scientist and pharmaceutical companies worldwide on the spot to develop novel …
The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory …
There is an unmet need for preclinical models to understand the pathogenesis of human
respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can …
respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can …