[HTML][HTML] Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression …

A Borsini, A Nicolaou, D Camacho-Muñoz… - Molecular …, 2021 - nature.com
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can exert antidepressant,
anti-inflammatory and neuroprotective properties, but the exact molecular mechanism …

The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting …

C Song, CH Shieh, YS Wu, A Kalueff, S Gaikwad… - Progress in lipid …, 2016 - Elsevier
Omega-3 polyunsaturated fatty acids (n‐3-PUFAs), mainly eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA), may improve or prevent some psychiatric and …

[HTML][HTML] Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of …

DY Lu, YY Tsao, YM Leung, KP Su - Neuropsychopharmacology, 2010 - nature.com
Accumulating evidence suggests that the pathophysiology of depression might be
associated with neuroinflammation, which could be attenuated by pharmacological …

Omega-3 polyunsaturated fatty acids and depression: a review of the evidence

R Liperoti, F Landi, O Fusco… - Current …, 2009 - ingentaconnect.com
Brain lipids contain a high proportion of polyunsaturated fatty acids (PUFA), which are a
main component of cell membranes. Omega-3 (ω-3) PUFA eicosapentaeoic acid (EPA) and …

[HTML][HTML] Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system

L Zhou, JY Xiong, YQ Chai, L Huang, ZY Tang… - Frontiers in …, 2022 - frontiersin.org
Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining
mental health and resistance to stress, and omega-3 PUFAs supplementation can display …

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet - Pharmacological reviews, 2018 - ASPET
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Biological mechanism of antidepressant effect of omega–3 fatty acids: how does fish oil act as a 'mind-body interface'?

KP Su - Neurosignals, 2009 - karger.com
The unsatisfactory results of monoamine-based antidepressant therapy and the high
occurrence of somatic symptoms and physical illness in patients with depression imply that …

[HTML][HTML] Omega-3 polyunsaturated fatty acids and oxylipins in neuroinflammation and management of Alzheimer disease

JG Devassy, S Leng, M Gabbs, M Monirujjaman… - Advances in …, 2016 - Elsevier
Alzheimer disease (AD) is becoming one of the most prevalent neurodegenerative
conditions worldwide. Although the disease progression is becoming better understood …

Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression

RP Bazinet, AH Metherel, CT Chen, SR Shaikh… - Brain, behavior, and …, 2020 - Elsevier
The results of several meta-analyses suggest that eicosapentaenoic acid (EPA)
supplementation is therapeutic in managing the symptoms of major depression. It was …

[HTML][HTML] The role of omega-3 fatty acids in preventing glucocorticoid-induced reduction in human hippocampal neurogenesis and increase in apoptosis

A Borsini, D Stangl, AR Jeffries, CM Pariante… - Translational …, 2020 - nature.com
Glucocorticoids have been suggested to be involved in several neuropsychiatric disorders,
including depression. One of the possible mechanisms through which glucocorticoids …