High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is present in almost
all cells and regulates the activity of innate immune responses in both intracellular and …

Despite recent advances in antibiotic therapy and intensive care, sepsis remains the most
common cause of death in the intensive care units, claiming approximately 225 000 victims …

Sepsis remains a significant health burden and a major clinical need exists for therapeutics
to dampen the excessive and uncontrolled immune activation. Nuclear protein high mobility …

High-mobility group box (HMGB)-1 was recently identified as a lethal mediator of severe
sepsis and represents a novel group of intracellular proteins that function as inflammatory …

High mobility group box 1 (HMGB1) is a highly conserved, ubiquitous protein present in the
nuclei and cytoplasm of nearly all cell types. In response to infection or injury, HMGB1 is …

Abstract High-mobility group box-1 (HMGB1) protein was originally described as a nuclear
DNA-binding protein that functions as a structural cofactor critical for proper transcriptional …

High-mobility group box 1 (HMGB1), a prototypical damage-associated molecular pattern
(DAMP) molecule, participates in multiple processes of various inflammatory diseases …

High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein present in the
nuclei and cytoplasm of nearly all cell types, is a necessary and sufficient mediator of …

High-mobility group box 1 (HMGB1) is a DNA-binding protein that also exhibits
proinflammatory cytokine-like activity. HMGB1 is passively released by necrotic cells and …

Sepsis remains a common cause of death in intensive care units, accounting for
approximately 20% of total deaths worldwide. Its pathogenesis is partly attributable to …