Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channels
EA Coppock, JR Martens… - American Journal of …, 2001 - journals.physiology.org
The hypoxia-induced membrane depolarization and subsequent constriction of small
resistance pulmonary arteries occurs, in part, via inhibition of vascular smooth muscle cell …
resistance pulmonary arteries occurs, in part, via inhibition of vascular smooth muscle cell …
Oxygen Sensitivity of Cloned Voltage-Gated K+ Channels Expressed in the Pulmonary Vasculature
JT Hulme, EA Coppock, A Felipe, JR Martens… - Circulation …, 1999 - Am Heart Assoc
Hypoxic pulmonary vasoconstriction is initiated by inhibiting one or more voltage-gated
potassium (Kv) channel in the vascular smooth muscle cells (VSMCs) of the small …
potassium (Kv) channel in the vascular smooth muscle cells (VSMCs) of the small …
Differential expression of KV channel α- and β-subunits in the bovine pulmonary arterial circulation
EA Coppock, MM Tamkun - American Journal of Physiology …, 2001 - journals.physiology.org
Resistance pulmonary arteries constrict in response to hypoxia, whereas conduit pulmonary
arteries typically do not respond or dilate slightly. One proposed mechanism for this …
arteries typically do not respond or dilate slightly. One proposed mechanism for this …
Potential role for Kv3. 1b channels as oxygen sensors
Hypoxia inhibits voltage-gated K channels in pulmonary artery smooth muscle (PASM). This
is thought to contribute to hypoxic pulmonary vasoconstriction by promoting membrane …
is thought to contribute to hypoxic pulmonary vasoconstriction by promoting membrane …
Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes
Chronic hypoxia results in both structural changes in the pulmonary artery and a sustained
increase in pulmonary vascular tone. This study investigated the effects of subacute …
increase in pulmonary vascular tone. This study investigated the effects of subacute …
Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery
J Wang, L Weigand, W Wang… - … of Physiology-Lung …, 2005 - journals.physiology.org
In pulmonary arterial smooth muscle cells (PASMCs), voltage-gated K+ (Kv) channels play
an important role in regulating membrane potential, cytoplasmic free Ca2+ concentration …
an important role in regulating membrane potential, cytoplasmic free Ca2+ concentration …
KV2.1 channels mediate hypoxic inhibition of IKV in native pulmonary arterial smooth muscle cells of the rat
DS Hogg, ARL Davies, G McMurray… - Cardiovascular …, 2002 - academic.oup.com
Objective: To determine whether, in native pulmonary arterial smooth muscle cells (PASMC),
KV2. 1 delayed-rectifying K+ channels are central to the process of hypoxic pulmonary …
KV2. 1 delayed-rectifying K+ channels are central to the process of hypoxic pulmonary …
Kv channel subunit expression in rat pulmonary arteries.
ARL Davies, RZ Kozlowski - Lung, 2001 - search.ebscohost.com
Hypoxic pulmonary vasoconstriction (HPV) is a mechanism whereby capillary perfusion is
modulated to match alveolar ventilation by diverting blood flow away from poorly ventilated …
modulated to match alveolar ventilation by diverting blood flow away from poorly ventilated …
Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage‐gated potassium channel Kv1. 5
Hypoxic pulmonary vasoconstriction (HPV) is initiated by the inhibition of several 4‐
aminopyridine (4‐AP)‐sensitive, voltage‐gated, K+ channels (Kv). Several O2‐sensitive …
aminopyridine (4‐AP)‐sensitive, voltage‐gated, K+ channels (Kv). Several O2‐sensitive …
Hypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cells.
Activity of voltage-gated K+ channels (KV) in pulmonary arterial smooth muscle cells
(PASMC) is pivotal in controlling membrane potential, cytoplasmic free Ca2+ concentration …
(PASMC) is pivotal in controlling membrane potential, cytoplasmic free Ca2+ concentration …