Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
A Hamacher-Brady, NR Brady, RA Gottlieb - Journal of Biological Chemistry, 2006 - ASBMB
Cardiac myocytes undergo programmed cell death as a result of ischemia/reperfusion (I/R).
One feature of I/R injury is the increased presence of autophagosomes. However, to date it …
One feature of I/R injury is the increased presence of autophagosomes. However, to date it …
Autophagy is impaired in cardiac ischemia-reperfusion injury
X Ma, H Liu, SR Foyil, RJ Godar, CJ Weinheimer… - Autophagy, 2012 - Taylor & Francis
Accumulating evidence attests to a prosurvival role for autophagy under stress, by facilitating
removal of damaged proteins and organelles and recycling basic building blocks, which can …
removal of damaged proteins and organelles and recycling basic building blocks, which can …
Oxidative stress stimulates autophagic flux during ischemia/reperfusion
N Hariharan, P Zhai, J Sadoshima - Antioxidants & redox signaling, 2011 - liebertpub.com
Autophagy is a bulk degradation process in which cytosolic proteins and organelles are
degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we …
degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we …
Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion
ÅB Gustafsson, RA Gottlieb - Autophagy, 2008 - Taylor & Francis
Autophagy is an important process in the heart which is responsible for the normal turnover
of long lived proteins and organelles. Inhibition of autophagy leads to the accumulation of …
of long lived proteins and organelles. Inhibition of autophagy leads to the accumulation of …
The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy
A Hamacher-Brady, NR Brady, RA Gottlieb - Cardiovascular Drugs and …, 2006 - Springer
Introduction Programmed cell death of cardiac myocytes occurs following a bout of
ischemia/reperfusion (I/R), which results in reduced function of the heart. Numerous studies …
ischemia/reperfusion (I/R), which results in reduced function of the heart. Numerous studies …
[HTML][HTML] The role and modulation of autophagy in experimental models of myocardial ischemia-reperfusion injury
C Chen-Scarabelli, PR Agrawal… - Journal of geriatric …, 2014 - ncbi.nlm.nih.gov
A physiological sequence called autophagy qualitatively determines cellular viability by
removing protein aggregates and damaged cytoplasmic constituents, and contributes …
removing protein aggregates and damaged cytoplasmic constituents, and contributes …
Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion
Y Matsui, S Kyoi, H Takagi, CP Hsu, N Hariharan… - Autophagy, 2008 - Taylor & Francis
Autophagy is an intracellular bulk degradation process whereby cytoplasmic proteins and
organelles are degraded and recycled through lysosomes. In the heart, autophagy plays a …
organelles are degraded and recycled through lysosomes. In the heart, autophagy plays a …
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
Y Matsui, H Takagi, X Qu, M Abdellatif… - Circulation …, 2007 - Am Heart Assoc
Autophagy is an intracellular bulk degradation process for proteins and organelles. In the
heart, autophagy is stimulated by myocardial ischemia. However, the causative role of …
heart, autophagy is stimulated by myocardial ischemia. However, the causative role of …
Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury
X Ma, H Liu, SR Foyil, RJ Godar, CJ Weinheimer… - Circulation, 2012 - Am Heart Assoc
Background—In myocardial ischemia, induction of autophagy via the AMP-induced protein
kinase pathway is protective, whereas reperfusion stimulates autophagy with BECLIN-1 …
kinase pathway is protective, whereas reperfusion stimulates autophagy with BECLIN-1 …
The autophagic response to nutrient deprivation in the hl‐1 cardiac myocyte is modulated by Bcl‐2 and sarco/endoplasmic reticulum calcium stores
NR Brady, A Hamacher‐Brady, H Yuan… - The FEBS …, 2007 - Wiley Online Library
Macroautophagy is a vital process in the cardiac myocyte: it plays a protective role in the
response to ischemic injury, and chronic perturbation is causative in heart disease. Recent …
response to ischemic injury, and chronic perturbation is causative in heart disease. Recent …