Cardiac myocytes undergo programmed cell death as a result of ischemia/reperfusion (I/R).
One feature of I/R injury is the increased presence of autophagosomes. However, to date it …

Accumulating evidence attests to a prosurvival role for autophagy under stress, by facilitating
removal of damaged proteins and organelles and recycling basic building blocks, which can …

Autophagy is a bulk degradation process in which cytosolic proteins and organelles are
degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we …

Autophagy is an important process in the heart which is responsible for the normal turnover
of long lived proteins and organelles. Inhibition of autophagy leads to the accumulation of …

Introduction Programmed cell death of cardiac myocytes occurs following a bout of
ischemia/reperfusion (I/R), which results in reduced function of the heart. Numerous studies …

A physiological sequence called autophagy qualitatively determines cellular viability by
removing protein aggregates and damaged cytoplasmic constituents, and contributes …

Autophagy is an intracellular bulk degradation process whereby cytoplasmic proteins and
organelles are degraded and recycled through lysosomes. In the heart, autophagy plays a …

Autophagy is an intracellular bulk degradation process for proteins and organelles. In the
heart, autophagy is stimulated by myocardial ischemia. However, the causative role of …

Background—In myocardial ischemia, induction of autophagy via the AMP-induced protein
kinase pathway is protective, whereas reperfusion stimulates autophagy with BECLIN-1 …

Macroautophagy is a vital process in the cardiac myocyte: it plays a protective role in the
response to ischemic injury, and chronic perturbation is causative in heart disease. Recent …