Skp2 and Slug are coexpressed in aggressive prostate cancer and inhibited by neddylation blockade
A Mickova, G Kharaishvili, D Kurfurstova… - International Journal of …, 2021 - mdpi.com
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in
Western countries, and there is still an urgent need for a better understanding of PCa …
Western countries, and there is still an urgent need for a better understanding of PCa …
High Skp2 expression is associated with a mesenchymal phenotype and increased tumorigenic potential of prostate cancer cells
Š Šimečková, Z Kahounová, R Fedr, J Remšík… - Scientific Reports, 2019 - nature.com
Skp2 is a crucial component of SCFSkp2 E3 ubiquitin ligase and is often overexpressed in
various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal …
various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal …
The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy
PL Nguyen, DI Lin, J Lei, M Fiorentino, E Mueller… - … Oncology: Seminars and …, 2011 - Elsevier
BACKGROUND: In several human cancers, overexpression of Skp2 (S-phase kinase
associated protein 2), which targets p27 for degradation, portends a poorer prognosis. We …
associated protein 2), which targets p27 for degradation, portends a poorer prognosis. We …
Skp2: a novel potential therapeutic target for prostate cancer
Z Wang, D Gao, H Fukushima, H Inuzuka, P Liu… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Prostate cancer is the most frequently diagnosed tumor in men and the second most
common cause of cancer-related death for males in the United States. It has been shown …
common cause of cancer-related death for males in the United States. It has been shown …
[HTML][HTML] Skp2 is associated with paclitaxel resistance in prostate cancer cells
Y Yang, Y Lu, L Wang, A Mizokami… - Oncology …, 2016 - spandidos-publications.com
Prostate cancer is the most commonly diagnosed tumor in men in the United States. Patients
with hormone-refractory prostate cancer are often treated with paclitaxel, but most of them …
with hormone-refractory prostate cancer are often treated with paclitaxel, but most of them …
Down-regulation of Skp2 is correlated with p27-associated cell cycle arrest induced by phenylacetate in human prostate cancer cells
T Shibahara, T Onishi, OE Franco, K Arima… - Anticancer …, 2005 - ar.iiarjournals.org
We have demonstrated that phenylacetate (PA)-induced cell cycle arrest in human prostate
cancer is mediated by increase of p27. In this study, we further investigated the mechanism …
cancer is mediated by increase of p27. In this study, we further investigated the mechanism …
Slug inhibits proliferation of human prostate cancer cells via downregulation of cyclin D1 expression
BACKGROUND Slug is a transcription factor of the Snail/Slug zinc‐finger family and is
implicated in metastasis of tumors, but its role in cell proliferation of prostate cancers is …
implicated in metastasis of tumors, but its role in cell proliferation of prostate cancers is …
Skp2 regulates androgen receptor through ubiquitin‐mediated degradation independent of Akt/mTOR pathways in prostate cancer
BACKGROUND The intervention of advanced prostate cancer (PCa) in patients has been
commonly depending on androgen deprivation therapy. Despite of tremendous research …
commonly depending on androgen deprivation therapy. Despite of tremendous research …
[HTML][HTML] Pharmacological inhibition of the SKP2/p300 signaling axis restricts castration-resistant prostate cancer
SKP2, an F-box protein of the SCF type of the E3 ubiquitin ligase complex, plays an
important function in driving tumorigenesis through the destruction of numerous tumor …
important function in driving tumorigenesis through the destruction of numerous tumor …
Downregulation of Snail by DUSP1 impairs cell migration and invasion through the inactivation of JNK and ERK and is useful as a predictive factor in the prognosis of …
D Martínez-Martínez, MV Toledo Lobo, P Baquero… - Cancers, 2021 - mdpi.com
Simple Summary The role of dual specificity phosphatase 1 (DUSP1) in metastasis-
associated processes in prostate cancer and its impact on patient outcome remains to be …
associated processes in prostate cancer and its impact on patient outcome remains to be …