Oxidized low-density lipoprotein (OxLDL), which contains hundreds of different oxidized lipid
molecules, is a hallmark of hyperlipidemia and atherosclerosis. The same oxidized lipids …

Oxidative tissue damage is a hallmark of many chronic inflammatory diseases. However, the
precise mechanisms linking oxidative changes to inflammatory reactions remain unclear …

Glycerophospholipids represent a common class of lipids critically important for integrity of
cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes …

Objective—Oxidized phospholipids (OxPLs) that are abundant in atherosclerotic lesions are
increasingly recognized as context-dependent lipid mediators demonstrating both pro-and …

Cardiovascular disease (CVD) is the number one cause of death in the United States and
worldwide. The most common cause of cardiovascular disease is atherosclerosis, or …

During inflammation or under conditions of oxidative stress, the polyunsaturated fatty acid
side chains of phospholipids in cellular membranes or lipoproteins can be oxidatively …

Oxidative modification of LDL is known to elicit an array of pro-atherogenic responses, but it
is generally underappreciated that oxidized LDL (OxLDL) exists in multiple forms …

Chronic inflammatory diseases including atherosclerosis are major causes of morbidity and
mortality worldwide. However, the factors, which trigger processes that determine the …

Oxidized phospholipids, such as the products of the oxidation of 1-palmitoyl-2-arachidonoyl-
sn-glycero-3-phosphocholine by nonenzymatic radical attack, are known to be formed in a …

Oxidized phospholipids are generally recognized as deleterious factors involved in disease
pathogenesis. This review summarizes the data suggesting that under certain biological …