Objective Wnt signaling is a master regulator of joint homeostasis, but its role in
osteoarthritis (OA) remains unclear. This study was undertaken to characterize the activation …

Abstract Objective Perturbation of Wnt signaling components reportedly regulates
chondrocyte fate and joint disorders. The Wnt inhibitor Dkk‐1 mediates remodeling of …

Objective Dkk is a family of canonical Wnt antagonists with 4 members (Dkk‐1, Dkk‐2, Dkk‐
3, and Dkk‐4). We undertook this study to explore the roles of Dkk‐1 and Dkk‐2 in …

Objective The results of recent animal studies suggest that activation of Wnt/β‐catenin
signaling in articular chondrocytes might be a driving factor in the pathogenesis of …

Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium.
The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important …

Abstract Purpose of Review Arthritis defines a large group of diseases primarily affecting the
joint. It is the leading cause of pain and disability in adults. Osteoarthritis (OA) affecting the …

Objective Osteoarthritis is a degenerative joint disease whose molecular mechanism is
currently unknown. Wnt/β‐catenin signaling has been demonstrated to play a critical role in …

Objective Tumor necrosis factor (TNF) drives bone destruction, but it also inhibits new bone
formation by inducing Dkk‐1, an inhibitor of the Wnt pathway. Accordingly, blocking of Dkk‐1 …

Activation and disruption of Wnt/β-catenin signaling both result in cartilage breakdown via
unknown mechanisms. Here we show that both WNT-3A and the Wnt inhibitor DKK1 …

Recent evidence from animal experiments and clinical samples points at a role for Wnt-
signaling in osteoarthritis (OA) pathology. These pathways are key inducers and regulators …