Toxicogenomic approaches for understanding molecular mechanisms of heavy metal mutagenicity and carcinogenicity
P Koedrith, HL Kim, JI Weon, YR Seo - International journal of hygiene and …, 2013 - Elsevier
Heavy metals that are harmful to humans include arsenic, cadmium, chromium, lead,
mercury, and nickel. Some metals or their related compounds may even cause cancer …
mercury, and nickel. Some metals or their related compounds may even cause cancer …
Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches
While scientific knowledge of the potential health significance of chemical exposures has
grown, experimental methods for predicting the carcinogenicity of environmental agents …
grown, experimental methods for predicting the carcinogenicity of environmental agents …
Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium
Y Chervona, A Arita, M Costa - Metallomics, 2012 - academic.oup.com
Carcinogenic metals, such as nickel, arsenic, and chromium, are widespread environmental
and occupational pollutants. Chronic exposure to these metals has been connected with …
and occupational pollutants. Chronic exposure to these metals has been connected with …
Classification of heavy-metal toxicity by human DNA microarray analysis
K Kawata, H Yokoo, R Shimazaki… - Environmental science & …, 2007 - ACS Publications
Microarray technology is proving to be a useful tool to classify undefined environmental
toxicants, to investigate underlying mechanisms of toxicity, and to identify candidate toxicant …
toxicants, to investigate underlying mechanisms of toxicity, and to identify candidate toxicant …
The comparative toxicogenomics database: update 2017
AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2017 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) provides
information about interactions between chemicals and gene products, and their …
information about interactions between chemicals and gene products, and their …
Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges
PD Ray, A Yosim, RC Fry - Frontiers in genetics, 2014 - frontiersin.org
Exposure to toxic metals poses a serious human health hazard based on ubiquitous
environmental presence, the extent of exposure, and the toxicity and disease states …
environmental presence, the extent of exposure, and the toxicity and disease states …
Toxicogenomic profiling of chemically exposed humans in risk assessment
Gene–environment interactions contribute to complex disease development. The
environmental contribution, in particular low-level and prevalent environmental exposures …
environmental contribution, in particular low-level and prevalent environmental exposures …
The state-of-the art of environmental toxicogenomics: Challenges and perspectives of “omics” approaches directed to toxicant mixtures
The last decade witnessed extraordinary advances in “omics” methods, particularly
transcriptomics, proteomics and metabolomics, enabling toxicologists to integrate …
transcriptomics, proteomics and metabolomics, enabling toxicologists to integrate …
Development of a toxicogenomics signature for genotoxicity using a dose‐optimization and informatics strategy in human cells
HH Li, DR Hyduke, R Chen, P Heard… - Environmental and …, 2015 - Wiley Online Library
The development of in vitro molecular biomarkers to accurately predict toxicological effects
has become a priority to advance testing strategies for human health risk assessment. The …
has become a priority to advance testing strategies for human health risk assessment. The …
Gene expression profiling to identify the toxicities and potentially relevant human disease outcomes associated with environmental heavy metal exposure
Heavy metals are the most commonly encountered toxic substances that increase
susceptibility to various diseases after prolonged exposure. We have previously shown that …
susceptibility to various diseases after prolonged exposure. We have previously shown that …