Toxicogenomic approaches for understanding molecular mechanisms of heavy metal mutagenicity and carcinogenicity

P Koedrith, HL Kim, JI Weon, YR Seo - International journal of hygiene and …, 2013 - Elsevier
Heavy metals that are harmful to humans include arsenic, cadmium, chromium, lead,
mercury, and nickel. Some metals or their related compounds may even cause cancer …

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches

KZ Guyton, AD Kyle, J Aubrecht, VJ Cogliano… - … Research/Reviews in …, 2009 - Elsevier
While scientific knowledge of the potential health significance of chemical exposures has
grown, experimental methods for predicting the carcinogenicity of environmental agents …

Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium

Y Chervona, A Arita, M Costa - Metallomics, 2012 - academic.oup.com
Carcinogenic metals, such as nickel, arsenic, and chromium, are widespread environmental
and occupational pollutants. Chronic exposure to these metals has been connected with …

Classification of heavy-metal toxicity by human DNA microarray analysis

K Kawata, H Yokoo, R Shimazaki… - Environmental science & …, 2007 - ACS Publications
Microarray technology is proving to be a useful tool to classify undefined environmental
toxicants, to investigate underlying mechanisms of toxicity, and to identify candidate toxicant …

The comparative toxicogenomics database: update 2017

AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2017 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) provides
information about interactions between chemicals and gene products, and their …

Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges

PD Ray, A Yosim, RC Fry - Frontiers in genetics, 2014 - frontiersin.org
Exposure to toxic metals poses a serious human health hazard based on ubiquitous
environmental presence, the extent of exposure, and the toxicity and disease states …

Toxicogenomic profiling of chemically exposed humans in risk assessment

CM McHale, L Zhang, AE Hubbard, MT Smith - Mutation Research/Reviews …, 2010 - Elsevier
Gene–environment interactions contribute to complex disease development. The
environmental contribution, in particular low-level and prevalent environmental exposures …

The state-of-the art of environmental toxicogenomics: Challenges and perspectives of “omics” approaches directed to toxicant mixtures

C Martins, K Dreij, PM Costa - International Journal of Environmental …, 2019 - mdpi.com
The last decade witnessed extraordinary advances in “omics” methods, particularly
transcriptomics, proteomics and metabolomics, enabling toxicologists to integrate …

Development of a toxicogenomics signature for genotoxicity using a dose‐optimization and informatics strategy in human cells

HH Li, DR Hyduke, R Chen, P Heard… - Environmental and …, 2015 - Wiley Online Library
The development of in vitro molecular biomarkers to accurately predict toxicological effects
has become a priority to advance testing strategies for human health risk assessment. The …

Gene expression profiling to identify the toxicities and potentially relevant human disease outcomes associated with environmental heavy metal exposure

HM Korashy, IM Attafi, KS Famulski, SA Bakheet… - Environmental …, 2017 - Elsevier
Heavy metals are the most commonly encountered toxic substances that increase
susceptibility to various diseases after prolonged exposure. We have previously shown that …