Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior
Depression alters the structure and function of brain reward circuitry. Preclinical evidence
suggests that medium spiny neurons (MSNs) in the nucleus accumbens (NAc) undergo …
suggests that medium spiny neurons (MSNs) in the nucleus accumbens (NAc) undergo …
The selective RhoA inhibitor rhosin promotes stress resiliency through enhancing D1-medium spiny neuron plasticity and reducing hyperexcitability
Background Nucleus accumbens dopamine 1 receptor medium spiny neurons (D1-MSNs)
play a critical role in the development of depression-like behavior in mice. Social defeat …
play a critical role in the development of depression-like behavior in mice. Social defeat …
Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress
TC Francis, R Chandra, DM Friend, E Finkel, G Dayrit… - Biological …, 2015 - Elsevier
Background The nucleus accumbens is a critical mediator of depression-related outcomes
to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in …
to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in …
Molecular basis of dendritic atrophy and activity in stress susceptibility
TC Francis, R Chandra, A Gaynor, P Konkalmatt… - Molecular …, 2017 - nature.com
Molecular and cellular adaptations in nucleus accumbens (NAc) medium spiny neurons
(MSNs) underlie stress-induced depression-like behavior, but the molecular substrates …
(MSNs) underlie stress-induced depression-like behavior, but the molecular substrates …
Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
Stress alters the structure and function of brain reward circuitry and is an important risk factor
for developing depression. In the nucleus accumbens (NAc), structural and physiological …
for developing depression. In the nucleus accumbens (NAc), structural and physiological …
Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of …
R Shinohara, M Taniguchi, AT Ehrlich… - Molecular …, 2018 - nature.com
Dopamine in prefrontal cortices is implicated in cognitive and emotional functions, and the
dysfunction of prefrontal dopamine has been associated with cognitive and emotional …
dysfunction of prefrontal dopamine has been associated with cognitive and emotional …
Dendritic spines in depression: what we learned from animal models
H Qiao, MX Li, C Xu, HB Chen, SC An… - Neural plasticity, 2016 - Wiley Online Library
Depression, a severe psychiatric disorder, has been studied for decades, but the underlying
mechanisms still remain largely unknown. Depression is closely associated with alterations …
mechanisms still remain largely unknown. Depression is closely associated with alterations …
Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex
C Numa, H Nagai, M Taniguchi, M Nagai… - Scientific reports, 2019 - nature.com
We recently reported that dopamine D1 receptor in the medial prefrontal cortex (mPFC) is
activated by subthreshold social defeat stress and suppresses the induction of depressive …
activated by subthreshold social defeat stress and suppresses the induction of depressive …
Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling
Y Chen, EA Kramár, LY Chen, AH Babayan… - Molecular …, 2013 - nature.com
Stress is ubiquitous in modern life and exerts profound effects on cognitive and emotional
functions. Thus, whereas acute stress enhances memory, longer episodes exert negative …
functions. Thus, whereas acute stress enhances memory, longer episodes exert negative …
Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Depression induces structural and functional synaptic plasticity in brain reward circuits,
although the mechanisms promoting these changes and their relevance to behavioral …
although the mechanisms promoting these changes and their relevance to behavioral …