Recombinant esterase from Corynebacterium pseudotuberculosis in DNA and subunit recombinant vaccines partially protects mice against challenge

AA Brum, AFS Rezende… - Journal of medical …, 2017 - microbiologyresearch.org
Purpose. We tested the efficacy of the esterase encoded by cp1002_RS09720 from
Corynebacterium pseudotuberculosis in recombinant subunit and DNA caseous …

[HTML][HTML] A novel approach for an immunogen against Corynebacterium pseudotuberculosis infection: An Escherichia coli bacterin expressing phospholipase D

RB de Pinho, MT de Oliveira Silva, G Brenner… - Microbial …, 2021 - Elsevier
Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis
(CLA) in small ruminants. There is still needed an immunoprophylaxis model, which induces …

Identification of new Corynebacterium pseudotuberculosis antigens by immunoscreening of gene expression library

CE Galvão, SP Fragoso, CE de Oliveira, O Forner… - BMC microbiology, 2017 - Springer
Background Caseous lymphadenitis (CLA) is a disease that affects sheep, goats and
occasionally humans. The etiologic agent is the Corynebacterium pseudotuberculosis …

Immunoprophylactic properties of the Corynebacterium pseudotuberculosis-derived MBP:PLD:CP40 fusion protein

TD Barral, MA Kalil, RB Mariutti, RK Arni… - Applied Microbiology …, 2022 - Springer
Caseous lymphadenitis (CLA) is a disease that affects small ruminants, and the best way to
prevent its spread on a herd is through immunoprophylaxis. Thus, we aimed to evaluate the …

Putative virulence factors of Corynebacterium pseudotuberculosis FRC41: vaccine potential and protein expression

KTO Santana-Jorge, TM Santos, NR Tartaglia… - Microbial cell …, 2016 - Springer
Background Corynebacterium pseudotuberculosis, a facultative intracellular bacterial
pathogen, is the etiological agent of caseous lymphadenitis (CLA), an infectious disease that …

[HTML][HTML] NanH and PknG putative virulence factors as a recombinant subunit immunogen against Corynebacterium pseudotuberculosis infection in mice

MT de Oliveira Silva, RB de Pinho… - Vaccine, 2020 - Elsevier
Despite the economic and zoonotic relevance of caseous lymphadenitis, a competent
immunoprophylaxis tool is still necessary. Here, we evaluated two putative virulence factors …

Association of Corynebacterium pseudotuberculosis recombinant proteins rCP09720 or rCP01850 with rPLD as immunogens in caseous lymphadenitis …

MT de Oliveira Silva, FSB Bezerra, RB de Pinho… - Vaccine, 2018 - Elsevier
Caseous lymphadenitis (CLA) is a chronic disease responsible for significant economic
losses in sheep and goat breeding worldwide. The treatment for this disease is not effective …

Targeting Improves the Efficacy of a DNA Vaccine against Corynebacterium pseudotuberculosis in Sheep

PJ Chaplin, R De Rose, JS Boyle… - Infection and …, 1999 - Am Soc Microbiol
ABSTRACT A large-scale DNA vaccination trial was performed with sheep to investigate
whether an antigen targeted by CTLA-4 enhanced and accelerated the humoral immune …

Recombinant CP40 from Corynebacterium pseudotuberculosis confers protection in mice after challenge with a virulent strain

D Droppa-Almeida, WLP Vivas, KKO Silva… - Vaccine, 2016 - Elsevier
Abstract Background Caseous Lymphadenitis (CLA) is a contagious, infectious, chronic
disease caused by Corynebacterium pseudotuberculosis, which affects mainly sheep and …

[HTML][HTML] Saponin-adjuvanted recombinant vaccines containing rCP00660, rCP09720 or rCP01850 proteins against Corynebacterium pseudotuberculosis infection in …

FSB Bezerra, MT de Oliveira Silva, AFS Rezende… - Vaccine, 2021 - Elsevier
Purpose rCP01850, rCP09729 and rCP00660 proteins from Corynebacterium
pseudotuberculosis, predicted as the three best targets to be used in vaccines against …