To understand how infection by Mycobacterium tuberculosis (Mtb) is modulated by host cell
phenotype, we characterized those host phagocytes that controlled or supported bacterial …

Chronic tuberculosis represents a major health problem for one-third of the world's
population today. A key question relevant to chronic tuberculosis is the physiological status …

In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter
strains with scRNA-seq to simultaneously acquire the host transcriptome, surface marker …

Mycobacterium tuberculosis (Mtb) infection is initiated in the distal airways, but the bacteria
ultimately disseminate to the lung interstitium. Although various cell types, including alveolar …

A central feature of Mycobacterium tuberculosis (Mtb) pathogenesis is the ability of Mtb to
survive within macrophages (MØ). Despite its critical importance, our appreciation of the …

Little is known about the biochemical environment in phagosomes harboring an infectious
agent. To assess the state of this organelle we captured the transcriptional responses of …

Macrophage activation involves metabolic reprogramming to support antimicrobial cellular
functions. How these metabolic shifts influence the outcome of infection by intracellular …

Macrophages are the primary host cells for Mycobacterium tuberculosis, the causative agent
of tuberculosis (TB), during its intracellular survival in humans. The pathogen has a …

Macrophages play a central role in mycobacterial pathogenesis. Recent work has
highlighted the importance of diverse macrophage types and phenotypes that depend on …

The success of Mycobacterium tuberculosis as a pathogen derives from its facile adaptation
to the intracellular milieu of human macrophages. To explore this process, we asked …