Neuroprotective effects of human bone marrow mesenchymal stem cells against cerebral ischemia are mediated in part by an anti-apoptotic mechanism

Y Zhang, S Yu, JP Tuazon, JY Lee… - Neural regeneration …, 2019 - journals.lww.com
Transplantation of human bone marrow mesenchymal stem cells (hMSCs) stands as a
potent stroke therapy, but its exact mechanism remains unknown. This study investigated the …

Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats

X Bao, J Wei, M Feng, S Lu, G Li, W Dou, W Ma, S Ma… - Brain research, 2011 - Elsevier
Mesenchymal stem cells (MSCs) have been successfully used for the treatment of
experimental stroke. However, the neurorestorative mechanisms by which MSCs improve …

Therapeutic time window of mesenchymal stem cells derived from bone marrow after cerebral ischemia

K Komatsu, O Honmou, J Suzuki, K Houkin, H Hamada… - Brain Research, 2010 - Elsevier
Intravenous transplantation of mesenchymal stem cells (MSCs) prepared from bone marrow
ameliorates functional deficits in rat cerebral infarction models. Although several hypotheses …

Early transplantation of human cranial bone-derived mesenchymal stem cells enhances functional recovery in ischemic stroke model rats

J Oshita, T Okazaki, T Mitsuhara, T Imura… - Neurologia medico …, 2020 - jstage.jst.go.jp
We analyzed the cell characteristics, neuroprotective, and transplantation effects of human
cranial bonederived mesenchymal stem cells (hcMSCs) in ischemic stroke model rats …

Comparisons of the therapeutic effects of three different routes of bone marrow mesenchymal stem cell transplantation in cerebral ischemic rats

H Zhang, X Xie, Y Xiong, S Liu, G Hu, W Cao, X Wu - Brain research, 2018 - Elsevier
Bone marrow mesenchymal stem cells (BMSCs) are mainly administered via three routes:
intra-arterial, intravenous and intracerebral. It has been reported that BMSC administration …

[HTML][HTML] Transplantation of mesenchymal stem cells promotes the functional recovery of the central nervous system following cerebral ischemia by inhibiting myelin …

N Feng, G Hao, F Yang, F Qu… - Experimental and …, 2016 - spandidos-publications.com
Cerebral ischemia, which may lead to cerebral hypoxia and damage of the brain tissue, is a
leading cause of human mortality and adult disability. Mesenchymal stem cells (MSCs) are a …

Systemically administered human bone marrow-derived mesenchymal stem home into peripheral organs but do not induce neuroprotective effects in the MCAo …

B Steiner, M Roch, N Holtkamp, A Kurtz - Neuroscience letters, 2012 - Elsevier
Mesenchymal stem cells (MSC) from bone marrow induce neuroprotective effects and
improve clinical symptoms in animal models for acute cerebral ischemia. So far only few …

Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia

W Zheng, O Honmou, K Miyata, K Harada, J Suzuki… - Brain research, 2010 - Elsevier
Although intravenous delivery of mesenchymal stem cells (MSCs) prepared from adult bone
marrow reduces infarction size and ameliorates functional deficits in rat middle cerebral …

Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats

LR Zhao, WM Duan, M Reyes, CD Keene… - Experimental …, 2002 - Elsevier
There is now evidence to suggest that bone marrow mesenchymal stem cells (MSCs) not
only differentiate into mesodermal cells, but can also adopt the fate of endodermal and …

Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral …

MJ Tsai, SK Tsai, BR Hu, DY Liou, SL Huang… - Journal of biomedical …, 2014 - Springer
Background Several lines of evidence have demonstrated that bone marrow-derived
mesenchymal stem cells (BM-MSC) release bioactive factors and provide neuroprotection …