A major obstacle in the application of cell-based therapies for the treatment of
neuromuscular disorders is obtaining the appropriate number of stem/progenitor cells to …

Direct reprogramming of adult fibroblasts to a pluripotent state has opened new possibilities
for the generation of patient-and disease-specific stem cells. However the ability of induced …

Skeletal muscle harbors quiescent stem cells termed satellite cells and proliferative
progenitors termed myoblasts, which play pivotal roles during muscle regeneration …

Recent reports have documented the differentiation of human pluripotent stem cells toward
the skeletal myogenic lineage using transgene-and cell purification-free approaches …

An effective long-term cell therapy for skeletal muscle regeneration requires donor
contribution to both muscle fibers and the muscle stem cell pool. Although satellite cells …

Human pluripotent stem cells (hPSCs) can be directed to differentiate into skeletal muscle
progenitor cells (SMPCs). However, the myogenicity of hPSC-SMPCs relative to human fetal …

Skeletal muscle is the most abundant human tissue; therefore, an unlimited availability of
myogenic cells has applications in regenerative medicine and drug development. Here we …

Muscle regeneration occurs through activation of quiescent satellite cells whose progeny
proliferate, differentiate, and fuse to make new myofibers. We used a transgenic Pax7 …

Human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are promising
sources for the cell therapy of muscle diseases and can serve as powerful experimental …

Duchenne muscular dystrophy is a progressive and incurable neuromuscular disease
caused by genetic and biochemical defects of the dystrophin–glycoprotein complex. Here …