Molecular testing for acute respiratory tract infections: clinical and diagnostic recommendations from the IDSA's Diagnostics Committee

KE Hanson, MM Azar, R Banerjee… - Clinical Infectious …, 2020 - academic.oup.com
The clinical signs and symptoms of acute respiratory tract infections (RTIs) are not pathogen
specific. Highly sensitive and specific nucleic acid amplification tests have become the …

[HTML][HTML] Evaluation of four commercial multiplex molecular tests for the diagnosis of acute respiratory infections

N Salez, A Vabret, M Leruez-Ville, L Andreoletti… - PLoS …, 2015 - journals.plos.org
Acute Respiratory Infections (ARIs) are responsible for considerable morbidity and mortality
worldwide. Documentation of respiratory specimens can help for an appropriate clinical …

[HTML][HTML] Clinical impact of rapid molecular detection of respiratory pathogens in patients with acute respiratory infection

M Echavarría, DN Marcone, M Querci, A Seoane… - Journal of Clinical …, 2018 - Elsevier
Background Acute respiratory infections (ARI) are a leading cause of morbidity and mortality
worldwide. There is a need to demonstrate the clinical impact of using the new, rapid and …

A host-based RT-PCR gene expression signature to identify acute respiratory viral infection

AK Zaas, T Burke, M Chen, M McClain… - Science translational …, 2013 - science.org
Improved ways to diagnose acute respiratory viral infections could decrease inappropriate
antibacterial use and serve as a vital triage mechanism in the event of a potential viral …

[HTML][HTML] Respiratory tract infections and laboratory diagnostic methods: a review with a focus on syndromic panel-based assays

A Calderaro, M Buttrini, B Farina, S Montecchini… - Microorganisms, 2022 - mdpi.com
Respiratory tract infections (RTIs) are the focus of developments in public health, given their
widespread distribution and the high morbidity and mortality rates reported worldwide. The …

Host gene expression classifiers diagnose acute respiratory illness etiology

EL Tsalik, R Henao, M Nichols, T Burke… - Science translational …, 2016 - science.org
Acute respiratory infections caused by bacterial or viral pathogens are among the most
common reasons for seeking medical care. Despite improvements in pathogen-based …

Point-of-care diagnostics for respiratory viral infections

K Basile, J Kok, DE Dwyer - Expert review of molecular diagnostics, 2018 - Taylor & Francis
Introduction: Successful treatment outcomes for viral respiratory tract infections presenting
from primary health care to quaternary hospitals will only be achieved with rapid, sensitive …

Practical guidance for clinical microbiology laboratories: viruses causing acute respiratory tract infections

CL Charlton, E Babady, CC Ginocchio… - Clinical microbiology …, 2018 - Am Soc Microbiol
Respiratory viral infections are associated with a wide range of acute syndromes and
infectious disease processes in children and adults worldwide. Many viruses are implicated …

Rapid point of care diagnostic tests for viral and bacterial respiratory tract infections—needs, advances, and future prospects

A Zumla, JA Al-Tawfiq, VI Enne, M Kidd… - The Lancet Infectious …, 2014 - thelancet.com
Respiratory tract infections rank second as causes of adult and paediatric morbidity and
mortality worldwide. Respiratory tract infections are caused by many different bacteria …

A blood-based host gene expression assay for early detection of respiratory viral infection: an index-cluster prospective cohort study

MT McClain, FJ Constantine, BP Nicholson… - The Lancet Infectious …, 2021 - thelancet.com
Background Early and accurate identification of individuals with viral infections is crucial for
clinical management and public health interventions. We aimed to assess the ability of …