[HTML][HTML] AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages

L Xia, C Zhang, N Lv, Z Liang, T Ma, H Cheng, Y Xia… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be
associated with pathogenesis of ALI (acute lung injury). Exosomes from adipose-derived …

BMSC‐derived exosomes ameliorate LPS‐induced acute lung injury by miR‐384‐5p‐controlled alveolar macrophage autophagy

X Liu, C Gao, Y Wang, L Niu, S Jiang… - Oxidative Medicine and …, 2021 - Wiley Online Library
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common critical
diseases. Bone marrow mesenchymal stem cell (BMSC) transplantation is previously shown …

Differential Lung Protective Capacity of Exosomes Derived from Human Adipose Tissue, Bone Marrow, and Umbilical Cord Mesenchymal Stem Cells in Sepsis …

H Deng, L Zhu, Y Zhang, L Zheng, S Hu… - Oxidative medicine …, 2022 - Wiley Online Library
Exosomes derived from human mesenchymal stem cells (hMSCs) have the capacity to
regulate various biological events associated with sepsis‐induced acute respiratory distress …

Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells

Y Mizuta, T Akahoshi, J Guo, S Zhang… - Stem Cell Research & …, 2020 - Springer
Abstract Background Mesenchymal stem cells (MSCs), including adipose-derived
mesenchymal stem cells (ADSCs), have been shown to attenuate organ damage in acute …

Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer

TJ Morrison, MV Jackson, EK Cunningham… - American journal of …, 2017 - atsjournals.org
Rationale: Acute respiratory distress syndrome (ARDS) remains a major cause of respiratory
failure in critically ill patients. Mesenchymal stromal cells (MSCs) are a promising candidate …

Bone marrow mesenchymal stem cell-derived exosomes attenuate LPS-induced ARDS by modulating macrophage polarization through inhibiting glycolysis in …

H Deng, L Wu, M Liu, L Zhu, Y Chen, H Zhou, X Shi… - Shock, 2020 - journals.lww.com
Macrophages play a key role in the development of sepsis-induced acute respiratory
distress syndrome (ARDS). Recent evidence has proved that glycolysis plays an important …

Mesenchymal stem cell-derived extracellular vesicles attenuate mitochondrial damage and inflammation by stabilizing mitochondrial DNA

M Zhao, S Liu, C Wang, Y Wang, M Wan, F Liu… - ACS …, 2020 - ACS Publications
Mitochondrial dysfunction is a key feature of injury to numerous tissues and stem cell aging.
Although the tissue regenerative role of mesenchymal stem cell (MSC)-derived extracellular …

[HTML][HTML] Exosomes released by bone marrow mesenchymal stem cells attenuate lung injury induced by intestinal ischemia reperfusion via the TLR4/NF-κB pathway

J Liu, T Chen, P Lei, X Tang… - International journal of …, 2019 - ncbi.nlm.nih.gov
Purpose: Acute lung injury (ALI) is a primary component of multiple organ dysfunction
syndromes triggered by intestinal ischemia-reperfusion (IIR) which results in high mortality …

Amnion epithelial cell-derived exosomes restrict lung injury and enhance endogenous lung repair

JL Tan, SN Lau, B Leaw, HPT Nguyen… - Stem cells …, 2018 - academic.oup.com
Idiopathic pulmonary fibrosis (IPF) is characterized by chronic inflammation, severe scarring,
and stem cell senescence. Stem cell-based therapies modulate inflammatory and fibrogenic …

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice

KP Maremanda, IK Sundar, I Rahman - Toxicology and Applied …, 2019 - Elsevier
Background Cigarette smoke (CS)-induced lung inflammation and Chronic Obstructive
Pulmonary disease (COPD) involves mitochondrial dysfunction. Mesenchymal stem cells …