Abstract Rationale Synucleinopathies, including Parkinson's disease (PD), multiple system
atrophy (MSA), and dementia with Lewy bodies (DLB), share a distinct pathological feature …

Parkinson's disease (PD) is the second most common neurodegenerative disease, after
Alzheimer's disease, and becomes increasingly prevalent with age. α-Synuclein (α-syn) …

Pathological aggregation of α-synuclein (α-syn) is a major component of Lewy bodies (LB),
which play a central role in pathogenesis of Parkinson's disease (PD). Differential …

α-Synuclein (α-syn) is a presynaptic protein that regulates the release of neurotransmitters
from synaptic vesicles in the brain. α-Syn aggregates, including Lewy bodies, are features of …

Fibrillary aggregated α-synuclein (α-syn) deposition in Lewy bodies (LB) characterizes
Parkinson's disease (PD) and is believed to trigger dopaminergic synaptic failure and a …

Abstract α‐Synuclein oligomers are thought to have a pivotal role in sporadic and familial
Parkinson's disease (PD) and related α‐synucleinopathies, causing dysregulation of protein …

Abstract Alpha-Synuclein (α-Syn) aggregation is a pathological feature of synucleinopathies,
neurodegenerative disorders that include Parkinson's disease (PD). Here, we explored the …

Inclusions composed of α-synuclein (α-syn), ie, Lewy bodies (LBs) and Lewy neurites (LNs),
define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy …

Accumulation of alpha-synuclein (ASYN) in neurons and other CNS cell types may
contribute to the underlying pathology of synucleinopathies including Parkinson's disease …

Accumulation of misfolded alpha-synuclein (α-syn) into Lewy bodies (LBs) and Lewy
neurites (LNs) is a major hallmark of Parkinson's disease (PD) and dementia with LBs …