The skewed T helper (Th) 2 response plays a critical role in the pathogenesis of allergic
asthma. Regulatory T (Treg) cells and the regulatory cytokines are required in maintaining …

Development of vaccines in autoimmune diseases has received wide attention over the last
decade. However, many vaccines showed limited clinical efficacy. To enhance vaccine …

Background Pollen allergy is the most common allergic disease. However, tropical pollens,
such as those of Palmae, have seldom been investigated compared with the specific …

Poly (lactic-co-glycolic acid)(PLGA) based nano/micro particles were investigated as a
potential vaccine platform for pertussis antigen. Presentation of pertussis toxoid as …

Allergic rhinitis (AR) is the most common respiratory allergic disorder which results from an
IgE-mediated inflammation in the nasal mucosa. The first strategies for the controlling of AR …

Allergic rhinitis (AR) is a common disease that requires more convenient, safe and effective
antigen‑specific immunotherapies. The present study aimed to investigate the therapeutic …

Background Asthma has been regarded as an inflammatory disease, and group 2 innate
lymphoid cells (ILC2s) are implicated in asthma pathogenesis. However, no strategy is …

Background: The efficacy of allergen-specific immunotherapy (AIT) is mainly depended on
the tolerogenic immune responses elicited. Properly conjugated nano-vaccine has the …

Many autoimmune diseases and other chronic inflammatory disorders are characterized by
defective FoxP3+ regulatory T-cell (Treg) mediated suppression. A potential treatment option …

Background and objective Biocompatible and biodegradable microparticles have gained
interest as antigen delivery systems during the recent years. We investigated whether …