Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its
clinical significance, there are still significant gaps in our understanding of pathogenic and …

Tuberculosis (TB) remains a major global health threat. Urgent needs in the fight against TB
include improved and innovative treatment options for drug-sensitive and-resistant TB as …

Mycobacterium tuberculosis is a virulent intracellular pathogen that survives in
macrophages even in the presence of an intact adaptive immune response. Type I IFNs …

Although the protective role of type II IFN, or IFN-γ, against Mycobacterium tuberculosis has
been established, the effects of type I IFNs are still unclear. One potential confounding factor …

The role of type I interferons (IFNs) in the host response to bacterial infections is
controversial. Here, we examined the role of IFN-α/β in the murine response to infection with …

Summary Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active
tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the …

Tuberculosis causes∼ 1.5 million deaths every year, thus remaining a leading cause of
death from infectious diseases in the world. A growing body of evidence demonstrates that …

Abstract The bacterium Mycobacterium tuberculosis (Mtb) causes tuberculosis and is
responsible for more human mortality than any other single pathogen. Progression to active …

Influenza followed by severe acute bacterial pneumonia is a major cause of mortality
worldwide. Several mechanisms account for this enhanced susceptibility, including …

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …