Ageing-associated functional decline of organs and increased risk for age-related chronic
pathologies is driven in part by the accumulation of senescent cells, which develop the …

Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct
changes in gene expression and the acquisition of a complex proinflammatory secretory …

Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought
to be an autonomous tumor-suppressor mechanism. During senescence, cells develop …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

Highlights•Senescent cells contribute to aging and age-related diseases.•Reducing the
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Anti‐senescence therapies, such as drugs that specifically kill senescent cells, to stave off
ageing are currently under investigation. While these interventions show promise, their …

Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …

Senescence is a stable cell cycle arrest that can be activated by oncogenic signaling and
manifests with changes in cellular organization and gene expression, such as the induction …